Natural substances are increasingly used in combination with synthetic drugs, because the resulting combinations are often less toxic, and more effective than either natural or synthetic drugs alone. Historically, the use of natural medicine was followed by the discovery of synthetic drugs, and in recent years, a resurgence in the use of natural substances -- which may have fewer negative side-effects, when compared with synthetic drugs. However, the amounts of phytochemicals in natural drugs is often insufficient unless combined with synthetic chemicals. At the same time, such combinations represent enormous complexity. Smart Therapeutics-Synergistic Combinations presents the state-of-the-art on such smart therapeutics, helping researchers develop new approaches for less toxic and more effective drug combinations. The book demonstrates that highly-toxic synthetic drugs may be rendered safe through synergistic combination with natural products. The volume consists in six parts, giving a historical overview; and covering drug development; drug interactions; synergic relations in drug discovery and combination therapy; calculations in designing synergistic combinations; and clinical approaches to synergistic combinations. This volume presents the latest work in combining natural and synthetic drugs for more effective, less toxic pharmaceuticals of use in clinical practice.