Introduction Burkhard Poeggeler 1. Therapeutic potential of genome editing tools in neurodegenerative diseases Ankur Kumar, Nandigam Pardhipa, Sachin G. Swami, Vibha Dwivedi and Anand K. Singh 2. Genetic and molecular basis of neurodegenerative diseases Sunanda Yogi, Anjali Sangeeth, Anuradha Venkatakrishnan Chimata, Radhika Padma and Amit Singh 3. Genome editing tools: principles, structures, and mechanisms Rayees Ahmad Naik, Mehak Naseer Mir, Roshni Rajpoot, Sonalika Singh, Kusum Singh and Sandeep Kumar Singh 4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseases Shailendra Kumar Mishra, Hung-Ming Chang, Ahmad A. Obaid and Sandeep Kumar Singh 5.

Use of CRISPR system in genetic screening to detect neurodegenerative disease Koyel Kar 6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseases Josephine Esposto 7. Transgene delivery system: viral, nonviral, and other methods for central nervous system Bhupender Sahu, Bibhudendu Behera and Umesh Kumar 8. Gene therapies for neurodegenerative disease: current knowledge and challenges Bhumi Arora, Sakshi Garg, Aditya Shrivastav, Mrinalini Sharma, Bhupender Sahu and Umesh Kumar 9. Gene therapy under clinical trials for neurodegenerative diseases Bhupender Sahu, Lakshita Tyagi, Prshant Tyagi and Umesh Kumar 10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics Burkhard Poeggeler.