To understand the potential hazard of a specific chemical, toxicologists must know both the type of effect it produces and the amount, or dose, required to produce that effect - the dose-response relationship. Although the general question remains the same over time, the tools and perspectives to answer this question have evolved to fully embrace biology and statistical/computational modeling. Uniquely dedicated to the topic of dose-response analysis, Dose-Response Analysis for Risk Assessment comprehensively reviews fundamental concepts and guides readers to understand advancing methods and practices. The book covers traditional practices widely accepted and used in the field alongside discussion of the novel approaches and concepts that are currently gaining more and more acceptance in the scientific community. The chapters address the challenges in characterizing both dose and response in a dose-response analysis, leading to more coherent understanding of dose-response relationship in an era of rapidly advancing biological and computational technologies. The combined chapters, by authors writing from the frontlines of risk assessment research, give readers a valuable reference and resource that: * Aids the interpretation of in vitro and in vivo data for chemical dose-response relationships, helping risk assessors derive acceptable or reference toxicity values * Brings together otherwise-scattered information and examples into one place for training and reference * Includes coverage of cancer, epidemiological data, physiologically-based pharmacokinetic (PBPK) and biologically-based dose-response (BBDR) modeling, data collection, cellular network modeling, toxicity threshold, and gene expression.