1 You Are Not Crazy "Am I Losing My Mind?" Between the ages of thirty and sixty, many women will wake up one morning and wonder what hit them. Whether it''s uncontrollable sweating or a barrage of brain fog and anxiety, any one of us can be confronted with an onslaught of peculiar changes sudden enough to, quite literally, make her head spin. It might be a sense of disorientation, where you find yourself doing increasingly absent-minded things, like entering a room only to wonder what made you go there in the first place. Belongings may be misplaced, with milk cartons finding their way into cabinets and cereal boxes ending up in the fridge. Communication can also become a challenge. Moments of sheer panic may arise as you struggle to come up with that word on the tip of your tongue or draw a blank on something you just said, losing your train of thought. Emotions, too, can be all over the place, as if a heavy darkness is causing you to weep for no clear reason-only to be replaced a moment later by waves of irritability or even anger. And just when you hoped a good night''s sleep might resolve these issues, sleep becomes elusive.

Like a fickle ghost, it visits sporadically throughout the night, or may not appear at all. With the rapid-fire onset and the intensity of these unexpected changes, it''s no wonder many feel as if their own bodies are betraying them, throwing any woman into a tailspin of questioning herself, her health, and even her sanity. Perhaps you don''t recognize any of these symptoms-yet. Most likely, though, you''ve heard about them before. From girlfriends, from your mother, from googling late at night when you can''t sleep . again. We now have a name for it: menopause brain. More often than not, the answer to the phenomena so many women experience in midlife is nothing more, but also nothing less, than menopause.

Menopause is one of the best-kept secrets in our society. Not only has there been no proper education or culture of support around this rite of passage common to all women, but often, menopause isn''t even discussed within families. What''s noteworthy is that even when there is some information or wisdom that''s shared, it''s generally not centered around the most prominent aspects of the transition-namely, how menopause impacts the brain. As a society, insofar as we have understood menopause at all, it''s generally only half of what it''s all about-the half that pertains to our reproductive organs. Most people are aware that menopause marks the end of a woman''s menstrual cycle and, therefore, her ability to bear children. But when the ovaries close up shop, the process has far broader and deeper effects than those associated with fertility. Far from the spotlight, menopause impacts the brain just as much as it impacts the ovaries-directly and powerfully, and in ways we are only beginning to gather real data about. What we do know is that all these baffling symptoms-the heat surges, the feelings of anxiety and depression, the sleepless nights, the clouded thoughts, the memory lapses-are, in fact, symptoms of menopause.

The real kicker, however, is that they don''t originate in the ovaries at all. They are initiated by another organ entirely: the brain. These are, in fact, neurological symptoms that come from the ways that menopause changes the brain. As much as your ovaries have their role in this process, it''s your brain that''s at the wheel. Does that make your worst fear real? Are you truly losing your mind? Not at all. I am here to reassure you that you are not going crazy. Most important to note: you are not alone in this, and you are going to be okay. While menopause does indeed impact the brain, that doesn''t mean the problems we experience are "all in our head.

" Just the opposite. The Hidden Scale and Impact of Menopause In our youth-obsessed culture, where it''s not outright dismissed, menopause is either dreaded or derided. Not only is there no acknowledgment of menopause as a noteworthy landmark in a woman''s life, but as it is historically perceived in the extreme negative, menopause comes with the stigmas associated with ageism, the demise of one''s vitality, and even the end of our identity as women. Mostly, however, menopause is framed in silence, sometimes even secrecy. Generations of women have suffered under misinformation, shame, and helplessness. Many remain reluctant to discuss their symptoms for fear of being judged, or strive to hide them. Most don''t even realize that what they''re experiencing has anything to do with menopause in the first place. All this confusion isn''t just unfair.

It constitutes a significant public health problem, with far-reaching consequences. Let''s look at the numbers: Women are half of the population. All women go through menopause. Women of menopausal age are by far the largest growing demographic group. By 2030, 1 billion women worldwide will have entered or will be about to enter menopause. Most women spend about 40 percent of their lives in menopause. All women, menopausal or not, possess an organ that has been largely ignored: the brain. Over three-quarters of all women develop brain symptoms during menopause.

Out of sheer numbers alone, menopause should be a major sociocultural event and the subject of extensive investigation and deep knowledge. Instead, whether we remain focused on the unpleasant symptoms or psyched out by the perceived lessening of our female powers, the current perception of what menopause means is fixated on the many pitfalls of this life event. Meanwhile, from a scientific and a medical perspective, it''s a discipline without a name. The Problem of Western Medical Frameworks Thanks to how genuinely uninformed we are about menopause, too many women are caught completely off guard, feeling betrayed by their body and their brain-not to mention their doctors, too. While hot flashes are generally recognized as a "side effect" of menopause, most doctors simply won''t make the connection between menopause and its other symptoms such as anxiety, insomnia, depression, or brain fog. This is especially the case for women under fifty, who are typically sent home with a prescription for antidepressants, their concerns dismissed as a by-product of their psychology, a sort of female existential crisis. Why is that? Western medicine is well known for its siloed, non-holistic frameworks, in which the human body is evaluated in terms of its individual components. For example, people with eye problems go to an eye doctor, and those with heart problems go to a cardiologist even if the heart problems led to the eye problems.

As a result of this extreme specialization, menopause has been pigeonholed as "an issue with the ovaries" and consigned to ob-gyn territory. Anyone who''s been there, however, knows that ob-gyns don''t do brains. Educated like every other doctor to specialize in specific body parts-in this case, the reproductive system-they aren''t trained to diagnose or manage brain symptoms in the first place. But also, many ob-gyns are not trained to manage menopause at all. Today, fewer than one in five ob-gyn residents receive formal training in menopause medicine, which often consists of a mere few hours in total. Perhaps unsurprisingly, 75 percent of women who seek care for menopausal symptoms end up not receiving treatment. On the other hand, brain doctors-neurologists and psychiatrists, among others-don''t handle menopause, either. Given these divided frameworks, it''s no surprise that the effects of menopause on brain health have been neglected, leaving these issues to fall into the cracks between rigidly defined medical disciplines.

Here''s where brain scientists come in handy. I am one of them, holding a somewhat unusual PhD in neuroscience (the study of how the brain works) and nuclear medicine (a branch of radiology that uses imaging techniques to examine the brain). But what really sets my work apart is that I have made it my life''s work to study and support women''s brains. Specifically, I am an associate professor of neuroscience in neurology and radiology at Weill Cornell Medicine in New York City, where I apply this background at the intersection of all these disciplines and women''s health. To this aim, in 2017, I launched the Women''s Brain Initiative, a clinical research program entirely and unapologetically dedicated to understanding how brain health plays out differently in women than in men. All day every day, my team studies women''s brains-how they work, what makes them uniquely powerful, what makes them uniquely vulnerable. At the same time, I am the director of the entire Alzheimer''s Prevention Program at Weill Cornell Medicine/NewYork-Presbyterian, which allows me to integrate my research on women''s brains with the clinical practice of evaluating and supporting cognitive and mental health for the long run. Years of research have made clear to me that caring for the health of the female brain requires a careful understanding of how it shifts and changes in response to our hormones, especially during menopause.

So one of the very first things I did after launching these programs was to pick up the phone and call the ob-gyn department. From that day on, we''ve been collaborating with some of the best menopause specialists around, as well as top-tier ob-gyn surgeons and oncologists. Together we set out to answer the question we didn''t see enough professionals exploring: How does menopause impact the brain? The Brain on Menopause When I started studying menopause, I qu.