This textbook is designed as a general introduction to the emerging discipline of biodiversity informatics. It is thus the first of its kind to describe the key components of how to deal with or use informatics techniques in order to manage biodiversity knowledge. Designed primarily for senior-level undergraduates and first- or second-year graduate students, this textbook provides a fundamental overview of the key concepts and techniques for managing biodiversity data. The textbook first starts by describing the management of information from database and natural language sources, then shifts to molecular data management, and finally suggests ways that biodiversity data can be used to inform other related disciplines.