This book comprises peer-reviewed papers from the fourth "International Conference of Reliable Systems Engineering (ICoRSE 2024)" that will take place in Bucharest, Romania, between 05 and 06 September 2024. The first three editions of the conference brought together participants from different countries in Europe, North America, and Asia, such as England, Albania, Austria, Bulgaria, Canada, Czech Republic, Germany, France, Italy, Portugal, Turkey, Ukraine, Uzbekistan, and Vietnam. The book presents state-of-the-art research in the field of mechatronics and other closely related areas and covers a wide range of topics in theoretical and applied mechanics: cyber-physical systems; research and developments in the field of robotics, artificial intelligence and computer visions; smart bio-medical and bio-mechatronic systems; new and intelligent materials and structures; modeling and simulation in mechanics and mechatronics; smart mechatronic production and control systems; optics systems; big data collecting, processing and analyzing; micro- and nanotechnology; automation; manufacturing optimization; and others. Since the book's chapters provide contributions of researchers and professionals in public and private organizations, they reflect a clear picture of the novelties attained in the leading-edge sciences that are in the scope of the conference. It is our belief that the book will be useful to both students and researchers in all areas of engineering, who will each find at least one topic worthy of their interest in this work.