This edited text discusses the state of the art of the human lymphatic system and its involvement in health and disease conditions. The modulation of lymphatic organs and their interplay could be valid strategies to prevent and treat different diseases, promoting a global healthy state. The authors emphasize the strict correlation between anatomic-morphological and functional changes and different pathophysiological states. This book is designed to encourage researchers to investigate the anatomic morphology of the lymphatic system and its correlation to different disease states.