Preface xv 1 State of the Art in Nanomedicine 1 Yujun Song and Wei Hou 1.1 Intractable Diseases and Development of the Related Novel Therapy and Medicines 1 1.2 Key Features of Nanomedicines 4 1.3 Nanotechnology Translational Nanomedicine: Emergence and Progress 6 1.4 Interdisciplinary Features of Nanomedicines: Multi-mode and Multi-function Features Promoting Nanomedicine-mediated Immunotherapy and/or Physical Field Ablation Therapy for Subversive Therapy 12 1.5 Future Development of Nanomedicines by Coupling Advanced Biomedicines (Including Biochemistry and Biophysics), Modern Physicochemical Technologies, and Artificial Intelligence Technology 27 2 Fundamentals in Nanomedicine 49 Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao 2.1 Design Theory of Nanomedicines 49 2.2 Progress in the Controlled Synthesis of Nanomaterials 55 2.

3 Progress in the Surface Modification and Functionalization of Nanomaterials for Nanomedicines 60 3 Nanomedicine for Antitumors 73 Qiong Wu, Xinzhu Yang, Ruixue Zhu, and Yujun Song 3.1 Introduction 73 3.2 Liposomal Nanoparticles 75 3.3 Polymeric Nanoparticles 78 3.4 Inorganic Nanoparticles 82 3.5 Mixture (Hybrid) Nanoparticles 90 3.6 Cell Membrane Coating Nanotechnology 93 3.7 Challenges and Current Limitations 94 3.

8 Conclusions 96 4 Nanomedicine for the Treatment of Nervous System Diseases 113 Xiaojian Cui and Yujun Song 4.1 Concepts and Types of Nanomedicines for Nervous System Diseases 113 4.2 Therapeutical Methods for Nervous System Diseases and Features of Current Nanomedicines 114 4.3 Synthesis Methods and Typical Examples (Including Clinical Trial) of Polymer-based Nanomedicines for Nervous System Diseases 116 4.4 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 117 4.5 Metallic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 122 4.6 Multifunctional Nanomedicines for Nervous System Diseases 125 5 Nanomaterial Translational Nanomedicine for Anti-HIV and Anti-bacterial 131 Hao Luo and Yujun Song 5.1 Concepts, Anti-HIV Theory, and Types and Features of Current Nanomedicines 132 5.

2 Polymer-based Nanomedicines: Synthesis Methods and Typical Application 142 5.3 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application 146 5.4 Metallic-based Nanomedicines: Synthesis Methods and Typical Application 148 5.5 Multi-functional (Target) Nanomedicines 150 5.6 Future Development 152 6 Nanomedicine for Next-generation Dermal Management 157 Haibin Wu, Qian Chen, and Shen Hu 6.1 Introduction 157 6.2 Nano-biomaterials-based Therapeutics forWound Healing 159 6.3 Nano-biomaterials for Imaging and Monitoring of Cutaneous Wounds 176 6.

4 Conclusion and Future Outlook 181 7 Nanomedicine for Targeting Delivery of Gene and Other DNA/RNA Therapies Based Viruses Engineering 197 Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao 7.1 Targeting Delivery of Gene Therapies to the Tumors 198 7.2 Targeting Delivery of Gene-based Nanovaccines to the Spleen 199 7.3 Targeting Delivery of Gene-based Nanovaccines to the LNs 200 7.4 Targeting Delivery of Gene-based Nanomedicines to the Liver 200 7.5 Targeting Delivery of Gene-based Nanomedicines to the Lung 200 7.6 Targeting Delivery of Gene-based Nanomedicines to the Brain 202 8 Nanomedicine for Bio-imaging and Disease Diagnosis 207 Ziqi Wang and Yujun Song 8.1 Concepts, Types, and Features of Current Nanoprobes 207 8.

2 Synthesis Methods 214 8.3 Typical Application Examples in the Disease Diagnosis and Study of Biological Events 219 8.4 Future Development 224 9 Magnetic Nanoparticles and Their Applications 227 Xiuyu Wang and Yuting Tang 9.1 Introduction 227 9.2 Classification of Magnetic Nanoparticles 228 9.3 Biomedical Applications 236 9.4 Conclusion and Outlook 242 10 Nanomedicine-mediated Immunotherapy 245 Wei Hou and Yujun Song 10.1 Immune System and Immune Response 245 10.

2 Mechanism of Tumor Immunotherapy 247 10.3 Mechanism of Nanomedicine-enhancing Immunotherapy 248 10.4 Immunological Applications of Nanomedicines 252 10.5 Summary and Outlook 263 11 Nanomedicine-mediated Ultrasound Therapy 269 Qingwei Liao, Yaoyao Liao, and Wei Si 11.1 Concept, Therapy Theory, and Devices 269 11.2 Nanomedicine Synthesis with Ultrasound Field Response 274 11.3 Application Examples 275 12 Nanomedicine-mediated Photodynamic and/or Photothermal Therapy 279 Shangqing Jing and Yujun Song 12.1 Photodynamic and Photothermal Mechanism for Anti-cancer 281 12.

2 Nanomaterial-based PSs (Nano-PSs) for PDT 283 12.3 Photodynamic and Photothermal Synergistic Therapy 291 12.4 Opportunities and Challenges 292 12.5 Summary 293 13 Nanomedicine-mediated Pulsed Electric Field Ablation Therapy 299 Xinzhu Yang, Qiong Wu, Ruixue Zhu, and Yujun Song 13.1 Introduction 299 13.2 Concept, Therapy Theory, and Devices 302 13.3 Synthesis of Nanomedicine with Electric Field Response 312 13.4 Application Examples 322 13.

5 Conclusion 323 14 Nanomedicine-mediated Magneto-dynamic and/or Magneto-thermal Therapy 329 Yangfei Wang and Yujun Song 14.1 Concepts, Treatment Theories, and Methods 329 14.2 Treatment Theories and Methods 330 14.3 Magnetic Field-responsive Nanomedicine Synthesis 333 14.4 Applications 337 15 Nanomedicine-mediated Radiotherapy for Cancer Treatment 341 Ruixue Zhu and Yujun Song 15.1 Concept, Therapy Theory, and Devices 341 15.2 Nanomaterials as Radiosensitizers for Radiation Therapy 347 15.3 Nanomaterials Delivering Radioisotope for Internal Radioisotope Therapy 358 15.

4 Nanomedicine Synthesis with Radio/Nuclear Radiation Response 362 15.5 Conclusion and Prospects 364 16 Nanomedicine Conjugating with AI Technology and Genomics for Precise and Personalized Therapy 371 Lin Liu, Siyu Chen, and Sen Zhang 16.1 Concept 371 16.2 Genomics of Nanomedicine 374 16.3 Artificial Intelligence Technology in Nanomedicine Development 377 16.4 Artificial Intelligence Facilitates Precise and Personalized Nanomedicine Based on Genomics 379 17 Microfluidic Conjugating AI Platform for High-throughput Nanomedicine Screening 385 Xing Huang, Wenya Liao, Zhongbin Xu, and Yujun Song 17.1 Introduction 385 17.2 Microfluidic Technologies for Medicine Development 386 17.

3 Microfluidic Preparation of Nanomedicines 391 17.4 Microfluidic High-throughput Drug Screening 396 17.5 AI-assisted Microfluidic Development of Nanomedicine 400 17.6 Conclusions and Perspectives 402 References 404 Index 413.