Part 1: Introduction 1. Overview of proteases of pathogenic organisms 2. Introducing endogenous macromolecular protease inhibitors of pathogenic organisms Part 2: New methods to identify protease substrates and inhibitors 3. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors 4. New advances in positional proteomics strategies to study protein processing 5. Bioinformatics approaches for accurate prediction of protease-specific substrates and their cleavage sites 6. Delineating peptidase specificities at the host-parasite interface using Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS) 7. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling 8.
Methods for mapping the mutational landscape of virus protease inhibitor binding sites to predict drug resistance Part 3: Aspartic proteases and their inhibitors 9. Bacterial signal peptidases 10. Plasmepsins of the malaria parasite Plasmodium 11. Aspartic proteases of kinetoplasts 12. HIV1 subtype C protease hinge region dynamics and flap flexibility in drug resistance 13. Aspartic protease inhibitors of nematodes Part 4: Cysteine proteases and their inhibitors 14. Polyprotein processing in SARS Cov-2 15. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms 16.
Sortases in pilus biogenesis of Gram-positive bacteria 17. Cysteine proteases of protozoa 18. Multifunctional Nidovirus papain-like proteases 19. Chagasins: Inhibitors of Cysteine Proteases in Protozoa 20. Targeting the 3C-like proteases of Picornaviruses, Noroviruses, and Coronaviruses Part 5: Metalloproteases and their inhibitors 21. The FusC about proteases involved in microbial iron piracy 22. Metallo-aminopeptidases in parasites and bacteria Part 6: Serine proteases and their inhibitors 23. Oligopeptidase B popping up in many pathogens as a virulence factor 24.
Ecotins of bacteria and protozoa 25. Serpins of trematodes and nematodes 26. Flaviviral serine NS2B-NS3 endoproteases Part 7: Threonine proteases 27. Proteasome in Plasmodium and kinetoplast parasites 28. Proteasome in infectious organisms.