The Handbook of Homotopy Theory provides a panoramic view of an active area in mathematics that is currently seeing dramatic solutions to long-standing open problems, and is proving itself of increasing importance across many other mathematical disciplines. The origins of the subject date back to work of Henri Poincaré and Heinz Hopf in the early 20th century, but it has seen enormous progress in the 21st century. A highlight of this volume is an introduction to and diverse applications of the newly established foundational theory of -categories. The coverage is vast, ranging from axiomatic to applied, from foundational to computational, and includes surveys of applications both geometric and algebraic. The contributors are among the most active and creative researchers in the field. The 22 chapters by 31 contributors are designed to address novices, as well as established mathematicians, interested in learning the state of the art in this field, whose methods are of increasing importance in many other areas.