In the 1920s general relativity, a macroscopic theory, met quantum mechanics, microscopic theory, head on and there was a clash and they never came together. Pieces were missing from both quantum mechanics and relativity. Those missing parts left quantum mechanics an approximation with no foundation and no correct connection to relativity. The failure persisted since one model was erroneously limited to the small and the other to the large. The fundamental problem that kept the theories separate hinged on an old mathematical difficulty of what constitutes a physical boundary between space. Taking on this problem has resulted in a major revision of quantum mechanics.
Fixing Physics : Not All Potentials Are Created Equal