Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structural and functional changes in tissues associated with the response to many toxicant classes including pharmaceuticals, biologies, innovative therapeutic products (cell and gene therapies as well as gene editing), vaccines, chemicals (both natural and manmade), metals, toxins, and physical agents such as radiation. Volumes 4 and 5 of the Fourth Edition, both titled "Toxicologic Pathology of Organ Systems", provide comprehensive coverage of the basic biology as well as key principles and procedures for evaluating toxicant-induced injury to essential organs and systems. Volume 4 addresses the digestive, hepatobiliary, skeletal, endocrine, and nervous systems as well as related organs including muscle (skeletal and smooth), tendon, pancreas, adipose tissue, eye, and ear. The remaining major organ systems are covered in Volume 5. The topics covered in Volume 4 of the Haschek and Rousseaux's Handbook of Toxicologic Pathology are an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions regarding various toxicants. This volume also is an essential reference for educators in this arena. Key Features, Completely revised and extensively expanded chapters on systems toxicologic pathology, A new chapter dedicated to adipose tissue biology and toxicology, Addition of teeth and tendon to existing chapters, New coverage of regulatory issues in each chapter, High-quality and trusted content in collaborative work written by leading international authorities in all areas of toxicologic pathology, Hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations.