VOLUME 1 Introduction: Hepatobiliary and Pancreatic Surgery: Historical Perspective PART 1 Liver, Biliary, and Pancreatic Anatomy and Physiology 1 Embryologic Development of the Liver, Biliary Tract, and Pancreas 2 Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas 3 Pancreatic Physiology and Functional Assessment 4 Assessment of Hepatic Function: Implications for Perioperative Outcome and Recovery 5 Liver Blood Flow: Physiology, Measurement, and Clinical Relevance 6 Liver Regeneration: Mechanisms and Clinical Relevance 7 Liver Fibrogenesis: Mechanisms and Clinical Relevance 8 Bile Secretion and Pathophysiology of Biliary Tract Obstruction 9A Molecular and cell Biology of Hepatopancreatobiliary Disease: Introduction and Basic Principles 9B Molecular and Cell Biology of Liver Carcinogenesis and Hepatitis 9C Advances in the Molecular Characterization of Liver Tumors 9D Advances in the Molecular Characterization of Pancreatic Cancer and Pre-malignant Lesions 9E Advances in the Molecular Characterization of Biliary Tract and Gallbladder Cancer 10 Fundamentals of Liver and Pancreas Immunology 11 Infections in Hepatic, Biliary, and Pancreatic Surgery PART 2 Diagnostic Techniques 12 Clinical Investigation of Hepatopancreatobiliary and Pancreatic Disease 13 Cross-Sectional Imaging of Liver, Biliary, and Pancreatic Disease: Introduction and Basic Principles 14 Imaging Features of Benign and Malignant Liver Tumors and Cysts 15 Imaging Features of Metastatic Liver Cancer 16 Imaging Features of Gallbladder and Biliary Tract Disease 17 Imaging Features of Benign and Malignant Pancreatic Disease 18 The Role of Nuclear Medicine in Diagnosis and Management of Hepatopancreatobiliary Diseases 19 Emerging Techniques in Diagnostic Imaging 20 Direct Cholangiography: Approaches, Techniques, and Current Role 21 Diagnostic Angiography in Hepatobiliary and Pancreatic Disease: Indications 22 Endoscopic Ultrasound of the Biliary Tract and Pancreas 23 Image-Guided Liver Biopsy 24 Intraoperative Diagnostic Techniques PART 3 Anesthetic Management, Pre- and Postoperative Care 25 Liver and Pancreatic Surgery: Intraoperative Management 26 Nutrition and Perioperative Critical Care in the Hepatopancreatobiliary Surgery Patient 27 Enhanced Recovery Programs in Hepatobiliary Surgery 28 Postoperative Complications Requiring Intervention: Diagnosis and Management 29 The Impact of Hepatobiliary Interventions on Health and Quality of Life and Health PART 4 Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical 30 Interventional Endoscopy for Biliary Tract Disease: Technical Aspects 31 Radiologic Hepatobiliary Interventions 32 Bile Duct Exploration and Biliary-Enteric Anastomosis PART 5 Biliary Tract Disease SECTION I Inflammatory, Infective, and Congenital A Gallstones and Gallbladder 33 The Natural History of Symptomatic and Asymptomatic Gallstones 34 Cholecystitis 35 Percutaneous Treatment of Gallbladder Disease 36 Cholecystectomy Techniques and Postoperative Problems 37A Stones in the Bile Duct: Clinical Features and Open Surgical Approaches and Techniques 37B Stones in the Bile Duct: Minimally Invasive Surgical Approaches 37C Stones in the Bile Duct: Endoscopic and Percutaneous Approaches 38 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When? 39 Intrahepatic Stone Disease B Biliary Stricture and Fistula 40 Extrahepatic Biliary Atresia 41 Primary Sclerosing Cholangitis 42 Benign Biliary Strictures and Biliary Fistulae C Biliary Infection and Infestation 43 Cholangitis 44 Recurrent Pyogenic Cholangitis 45 Biliary Parasitic Disease D Cystic Disease of the Biliary Tract 46 Bile Duct Cysts in Adults SECTION II Neoplastic A General 47 Tumors of the Bile Ducts: Pathologic Features B Benign Tumors 48 Benign Tumors and Pseudotumors of the Biliary Tract 49 Tumors of the Gallbladder 50 Intrahepatic Cholangiocarcinoma 51A Extrahepatic Biliary Tumors 51B Perihilar Cholangiocarcinoma: Presurgical Management 52 Interventional Techniques in Hilar and Intrahepatic Biliary Strictures PART 6 Pancreatic Disease SECTION I Inflammatory, Infective, and Congenital A Congenital Disorders 53 Congenital Disorders of the Pancreas: Surgical Considerations B Pancreatitis 54 Definition and Classification of Pancreatitis 55 Etiology, Pathogenesis, and Diagnostic Assessment of Acute Pancreatitis 56 Management of Acute Pancreatitis and Pancreatitis-Related Complications 57 Etiology, Pathogenesis, and Diagnosis of Chronic Pancreatitis 58 Management of Chronic Pancreatitis: Conservative, Endoscopic, Surgical SECTION II Neoplastic A General 59 Tumors of the Pancreas and Ampulla B Benign and Premalignant Tumors 60 Cystic Neoplasms of the Pancreas: Epidemiology, Clinical Features, Assessment, and Management C Malignant Tumors 61 Pancreatic Cancer: Epidemiology 62 Pancreatic Cancer: Clinical Aspects, Assessment, and Management 63 Duodenal Adenocarcinoma 64 Pancreas as a Site of Metastatic Cancer D Endocrine Tumors 65 Pancreatic Neuroendocrine Tumors: Classification, Clinical Picture, Diagnosis, and Therapy 66 Chemotherapy and Radiotherapy for Pancreatic Cancer: Adjuvant, Neoadjuvant, and Palliative 67 Palliative Treatment of Pancreatic and Periampullary Tumors VOLUME 2 PART 7 Hepatic Disease SECTION I Inflammatory, Infective, and Congenital A Hepatitis 68 Chronic Hepatitis: Epidemiology, Clinical Features, and Management 69 Hepatic Steatosis, Steatohepatitis, and Chemotherapy-Related Liver Injury B Liver Infection and Infestation 70 Pyogenic Liver Abscess 71 Amebiasis and Other Parasitic Infections 72 Hydatid Disease of the Liver C Nonparasitic Liver Cysts 73 Simple Cysts and Polycystic Liver Disease: Clinical and Radiographic Features and Surgical and Nonsurgical Management D Hepatic Cirrhosis, Portal Hypertension, and Hepatic Failure 74 Cirrhosis and Portal Hypertension: Pathologic Aspects 75 Nonhepatic Surgery in the Cirrhotic Patient 76 Portal Hypertension in Children 77 Management of Liver Failure 78 Support of the Failing Liver 79 Management of Ascites in Cirrhosis and Portal Hypertension 80 Medical Management of Bleeding Varices: Primary and Secondary Prophylaxis for Variceal Bleeding 81 Portal Hypertensive Bleeding: Acute Management 82 Portal Hypertensive Bleeding: Operative Devascularization 83 Portal Hypertensive Bleeding: the Role of Portosystemic Shunting 84 Techniques of Portasystemic Shunting: Selective and Nonselective Shunts 85 Transjugular Portosystemic Shunting (TIPS): Indications and Technique 86 Budd-Chiari Syndrome and Veno-Occlusive Disease SECTION II Neoplastic A General 87 Tumors of the Liver: Pathologic Aspects B Benign and Premalignant Tumors 88A Benign Liver Lesions 88B Cystic Hepatobiliary Neoplasia 89 Hepatocellular Carcinoma 90 Hepatic Metastasis from Colorectal Cancer 91 Hepatic Metastasis from Neuroendocrine Cancers 92 Hepatic Metastasis from Noncolorectal Nonneuroendocrine Tumors 93 Hepatic Tumors in Childhood D Treatment: Nonresectional 94A Hepatic Artery Embolization and Chemoembolization of Liver Tumors 94B Radioembolization for Liver Tumors 95 External Beam Radiotherapy for Liver Tumors 96A Ablative Treatment of Liver Tumors: Overview 96B Radiofrequency Ablation of Liver Tumors 96C Microwave Ablation and Irreversible Electroporation of Liver Tumors 96D Cryotherapy and Ethanol Injection 97 Regional Chemotherapy for Liver Tumors 98 Systemic Chemotherapy for Colorectal Liver Metastasis: Impact on Surgical Management 99 Advances in Systemic Therapy for Hepatocellular Carcinoma 100 Isolated Hepatic Perfusion for Unresectable Hepatic Metastases E Treatment: Resection 101A Hepatic Resection: General Considerations 101B Hepatic Resection for Benign and Malignant Liver and Biliary Tract Disease: Indications and Outcomes 102A Parenchymal Preservation in Hepatic Resectional Surgery: Rationale, Indications and Outcomes 102B Segment-Oriented Anatomic Liver Resections: Indications and Outcomes 102C Preoperative Portal Vein Embolization: Indications, Technique, and Results 102D Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Indications and Outcomes 103 Adjuncts to Hepatic Resection: From Ultrasound Guidance to New Oncologic and Technical Horizons PART 8 Liver and Pancreas Transplantation SECTION I General 104 Liver and Pancreas Transplantation Immunobiology SECTION II Indications 105 Liver Transplantation: Indications and General Considerations 106 Liver Transplantation: Perioperative Anesthetic Considerations 107 Liver Transplantation in Patients with Fulminant Hepatitis 108A Liver Transplantation for Hepatocellular Carcinoma 108B Liver Transplantation for Nonhepatocellular Malignant Disease 109 Orthotopic Liver Transplantation: Standard Donation After Brain Death, Donation After Cardiac Death, and Live Donor - Indications and Outcomes 110 Liver Transplantation in Children: Indications and Outcomes 111 Early.