This issue of Surgical Clinics of North America focuses on Surgical Challenges of Foregut Malignancies and is edited by Dr. Sushanth Reddy. Articles will include: Molecular basis of gastric and esophageal tumors; Multidisciplinary therapy of gastric cancers; Management of early stage gastric and esophageal disease; What is the best operation for proximal gastric cancer and distal esophageal cancer?; The difficult esophageal conduit; Managing the Western patient in contrast to the Eastern patient; Complications after esophagectomy; Next generation sequencing in the management of gastric and esophageal cancers; Managing squamous cell esophageal cancer; Esophageal and gastric GISTs; Surgical Challenges of Foregut Malignancies; and more!.