In this issue of Medical Clinics of North America, guest editor Dr. Marie Krousel-Wood brings her considerable expertise to the topic of Current Challenges and New Directions in Preventive Medicine. Top experts in the field provide evidence-based recommendations and strategies for common preventative medicine topics, including screening and vaccinations. Contains 13 relevant, practice-oriented topics including vaccine preventable diseases and vaccine hesitancy; substance use/opioid use disorder and clinical care; obesity-implementing evidence: strategies in clinical practice; healthcare providers and staff coping and burnout in the era of COVID-19; lifestyle medicine; and more. Provides in-depth clinical reviews on preventive medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.