1 Introduction 2 DNA-Compatible Organic Reactions 2.1 Amide-Bond-Forming Reactions 2.2 Metal-Promoted DEL-Compatible C--C Bond Forming Reactions 2.3 Metal-Free DEL-Compatible C--C Bond Forming Reactions 2.4 On-DNA C--X (X = N, O, P, S, Se) Bond Forming Reactions 2.5 On-DNA C--H Transformations 2.6 On-DNA Photoredox-Catalyzed Reactions 2.7 On-DNA Cyclization Reactions 2.

8 DNA-Encoded Isocyanide Multicomponent Reactions 2.9 On-DNA Functional-Group Transformations 2.10 Reversible Immobilization of DNA for Chemical Modification 2.11 Covalent Attachment on a Solid Support 2.12 Micelle-Mediated Synthesis 3 DEL Encoding and Setup Strategies 3.1 DNA-Templated Synthesis 3.2 DNA-Recorded Synthesis 3.2.

1 Single Pharmacophore Libraries 3.2.1.1 Encoding Using Double-Stranded DNA: A Headpiece-Based DNA Ligation Strategy 3.2.1.2 Encoding Using Single-Stranded DNA (Iterative Splint-Ligation Procedures) 3.2.

1.3 Chemical Ligation/Encoding 3.2.2 Dual-Pharmacophore Libraries 3.2.2.1 Encoded Self-Assembling (Dynamic) Chemical Libraries 3.2.

2.2 Peptide Nucleic Acid (PNA) Encoded Libraries 3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries 3.2.3 Special Libraries 3.2.

3.1 Macrocyclic DELs 3.2.3.2 Natural-Product-Enriched DELs 4 Library Selection Procedures 4.1 Selections by Affinity Capture on Solid Support 4.2 DEL Selection Using DNA-Programmed Affinity Labelling (DPAL) 4.3 Selections of DNA-Encoded Libraries to Protein Targets on Living Cells 4.

4 Selections of DNA-Encoded Libraries to Protein Targets within Living Cells 5 Evaluation/Cheminformatic Methods 5.1 Informatic Tools, Processing, and Evaluation of DEL Selection Data 5.2 On-DNA Resynthesis and Affinity Selection Mass Spectrometry (ASMS).