History and Evolution of Intrathecal Drug Delivery Intraspinal Anatomy: Considerations in Intrathecal Drug Delivery Spinal Target Receptors in Intrathecal Drug Delivery Mechanisms of Action of Intrathecally Administered Agents Physicochemical Properties and Compounding of Intrathecally Administered Agents Cerebrospinal Fluid Flow Dynamics Uptake and Distribution of Intrathecally Administered Agents Animal Models of Intrathecal Drug Delivery: Clinical Correlates Intrathecal Drug Delivery for Pain: Medical Considerations Intrathecal Drug Delivery for Pain: Psychological Considerations Intrathecal trialing Techniques for Pain Indications Catheter Localization and Programming Parameters for Pain Maintenance and Troubleshooting of Intrathecal Therapy for Pain Intrathecal Agents: Choices for Pain Intrathecal Therapy for Cancer Pain: Best Practices Intrathecal Therapy for Non-Cancer Pain: Best Practices Managing Complications of Intrathecal Therapy for Pain Assessing Patients with Movement Disorders for Intrathecal Therapy Trialing Techniques for Spasticity Catheter Localization and Programming Parameters for Spasticity Intrathecal Agents Use for Spasticity Maintenance and Troubleshooting of Intrathecal Therapy for Spasticity Managing Complications of Intrathecal Therapy for Spasticity System Choices Implantation Techniques Preoperative Considerations Managing Surgical Complications Special Patient Populations (Children, Anticoagulation, Other implanted devices) Cost Effectiveness of Intrathecal Drug Delivery Keys to Managing a Successful Targeted Drug Delivery Practice e-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Targeted Drug Delivery: Beyond the Spinal Canal.