Section I. Molecular Pathology of Pediatric Neoplasms: General Principles 1. Principles of Molecular Biology 1.1. Nucleic acid structure, composition and organization 1.2. Gene structure, organization, expression 1.3.
Chromosome structure 1.4. Circulating nucleic acid 1.5. Mitochondrial DNA 2. Molecular Oncogenesis 2.1. Oncogenes 2.
2. Tumor suppressor genes 2.3. Genomic alterations 2.4. Oncogenic viruses 2.5. Genomic landscape of pediatric neoplasms 3.
Molecular Testing in Oncology 3.1. Indications 3.2. Considerations for selection of a molecular test 3.3. Ethical considerations 3.4.
Specimen requirements 3.5. Specimen collection and processing 3.6. Interpretation of molecular testing results 4. Molecular Methods in Oncology: Targeted Mutational Analysis 4.1. PCR-based techniques 4.
2. FISH 5. Molecular Methods in Oncology: Genomic Analysis 5.1. Next-generation sequencing 5.2. Chromosomal microarray 6. Molecular Targeted Therapy of Pediatric Neoplasms Section II.
Molecular Pathology of Specific Pediatric Neoplasms 7. Hematolymphoid System 7.1. Childhood leukemias 7.2. Childhood myelodysplastic syndrome 7.3. Childhood lymphomas 8.
Nervous System 8.1. Gliomas 8.1.1. Low-grade gliomas 8.1.2.
High-grade gliomas 8.1.3. Diffuse intrinsic pontine glioma 8.2. Astrocytomas 8.2.1.
Low-grade astrocytomas 8.2.2. High-grade astrocytoma 8.2.3. Pleomorphic xanthoastrocytoma 8.3.
Atypical teratoid rhabdoid tumors 8.4. Ependymoma 8.5. Subependymal giant cell tumor 8.6. Medulloblastoma 8.7.
Craniopharyngioma 8.8. Choroid plexus tumors 8.9. Retinoblastoma 9. Neuroblastoma and neuroblastic tumors 10. Skin, Soft Tissue and Bone 10.1.
Melanocytic neoplasms 10.2. Langerhans cell histiocytosis 10.3. Nodular fasciitis 10.4. Fibromatosis 10. 5.
Rhadomyosarcoma 10.6. Desmoplastic small round cell tumor 10.7. Ewing sarcoma family 10.8. Synovial sarcoma 10.9.
Malignant peripheral nerve sheath tumor 10.10. Vascular neoplasms 10.11. Giant cell tumor 10.12. Aneurysmal bone cyst 10.13.
Fibrous dysplasia/McCune-Albright syndrome 10.14. Oste oblastoma 10.15. Osteosarcoma 10.16. Rare pediatric soft tissue neoplasms 11. Head and Neck 11.
1. Salivary gland neoplasms 11.2. Thyroid and parathyroid neoplasms 12. Cardiovascular and Respiratory System 12.1. Pleuropulmonary blastoma 12.2.
Inflammatory myofibroblastic tumor 12.3. Histiocytoid cardiomyopathy 13. Gastrointestinal Tract 13.1. Gastrointestinal stromal tumor 13.2. Juvenile polyposis syndrome 13.
3. Familial adenomatous polyposis 13.4. Peutz-Jeghers syndrome 13.5. Cronkhite-Canada syndrome 13.6. PTEN hamartoma tumor syndromes 13.
7. Cowden syndrome 13.8. Bannayan-Riley-Ruvalcaba syndrome 14. Liver and Pancreas 14.1. Hepatoblastoma 14.2.
Hepatocellular carcinoma 14.3. Pancreatoblastoma 15. Genitourinary 15.1. Wilms tumor 15.2. MITF/TFE family translocation-associated carcinoma.