von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology Immunobiology and Metabolic Pathways of Renal Cell Carcinoma Hereditary Renal Cell Carcinoma Syndromes The Role of the Pathologist in Renal Cell Carcinoma Management Insights into Renal Cell Carcinoma with Novel Imaging Approaches Surgical Management of Localized Disease and Small Renal Masses Role of Surgery in Metastatic Renal Cell Carcinoma Adjuvant and Neoadjuvant Therapy in Renal Cell Carcinoma Role of Radiation in Treatment of Renal Cell Carcinoma Prognostic Models in Metastatic Renal Cell Carcinoma Emerging Biomarkers of Response to Systemic Therapies in Metastatic Clear Cell Renal Cell Carcinoma Managing First-Line Metastatic Renal Cell Carcinoma: Favorable-Risk Disease First-Line Treatment for Intermediate and Poor Risk Advanced or Metastatic Clear Cell Renal Cell Carcinoma Managing Metastatic Renal Cell Carcinoma after Progression on Immunotherapy Renal Cell Carcinoma of Variant Histology: Biology and Therapies Toxicity Management of Systemic Kidney Cancer Therapies Management of Brain Metastases in Metastatic Renal Cell Carcinoma Novel Targeted Therapies for Renal Cell Carcinoma: Building on the Successes of Vascular Endothelial Growth Factor and mTOR Inhibition Novel Immune Therapies for Renal Cell Carcinoma: Looking Beyond the Programmed Cell Death Protein 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Axes.