In this issue of Anesthesiology Clinics, guest editor Dr. Shamsuddin Akhtar brings his considerable expertise to the topic of Geriatric Anesthesia. Top experts in the field cover key topics such as cardiovascular changes in the elderly; perioperative pulmonary complications in the elderly; frailty, sarcopenia, aging, and perioperative outcomes; perioperative delirium; and more. Contains 18 relevant, practice-oriented topics including central nervous system changes in the elderly: new Insights; data science and geriatric anesthesia research: opportunity and challenges; aging, COVID, and perioperative care; balancing efficiency, empathy, safety, and quality; pain management in the elderly; and more. Provides in-depth clinical reviews on geriatric anesthesia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.