About the Companion Website xvii Section 1 Anatomy of the Pancreas 1 1 Development of the Pancreas and Related Structures 3 Brian Lewis and Junhao Mao 2 Anatomy, Histology, and Fine Structure of the Pancreas 9 Daniel S. Longnecker and Elizabeth D. Thompson 3 Congenital and Inherited Anomalies of the Pancreas 23 Heiko Witt and Martin Zenker Section 2 Physiology and Pathophysiology of Pancreatic Functions 33 4 Physiology of Acinar Cell Secretion 35 Ole H. Petersen 5 Physiology of Duct Cell Secretion 48 Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem 6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56 Savio George Barreto and James Toouli 7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65 Chung Owyang and Matthew J. DiMagno 8 Regulation of Pancreatic Protein Synthesis and Growth 75 Maria Dolors Sans and John A. Williams 9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86 Minoti V. Apte, Romano C. Pirola, and Jeremy S.
Wilson 10 Pancreatic Endocrine-Exocrine Relationship 98 Kenichiro Furuyama and Yoshiya Kawaguchi Section 3 Acute Pancreatitis 105 11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107 Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte 12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119 Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama 13 Genetic Factors in Acute Pancreatitis 128 Mitchell L. Ramsey and Georgios I. Papachristou 14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138 Alistair B.J. Escott, Anthony R.
J. Phillips, and John A. Windsor 15 The Role of Neurogenic Inflammation in Pancreatitis 146 Metrah Mohammad Nader and Jami L. Saloman 16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155 Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle 17 Histopathology of Acute Pancreatitis 164 Günter Klöppel 18 Severity Classification of Acute Pancreatitis 170 John A. Windsor 19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176 Bettina M.
Rau and Claus Schäfer 20 Acute Pancreatitis Associated with Congenital Anomalies 185 Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit 21 Acute Pancreatitis in Children 191 Mark E. Lowe and Véronique D. Morinville 22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199 Ali A. Aghdassi, Mats L.
Wiese, Quang Trung Tran, and Markus M. Lerch 23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208 Yoshihisa Tsuji 24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222 Steven M. Hadley, Jr. and Timothy B. Gardner 25 ICU Treatment of Severe Acute Pancreatitis 230 Scott R. Gunn and David C. Whitcomb 26 Clinical Course and Medical Treatment of Acute Pancreatitis-- Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238 Rainer Isenmann and Mathias Wittau 27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244 Lily V. Saadat and Thomas E.
Clancy 28 Management of Infected Necrosis: Step- Up Approach 254 Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort 29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260 Todd H. Baron 30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266 Kulbir Mann and Michael G.T. Raraty 31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome 271 Dongya Huang, Zipeng Lu, and Yi Miao 32 Endoscopic Treatment of Acute Biliary Pancreatitis 278 Ichiro Yasuda, Tsuyoshi Mukai, and Toru Ito 33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 284 Georg Beyer and Julia Mayerle 34 Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Surgical Approach 288 Naohiro Sata, Masaru Koizumi, and Alan Kawarai Lefor 35 Management of Fluid Collection in Acute Pancreatitis 294 Georg Beyer, Simon Sirtl, Christoph Ammer- Herrmenau, and Albrecht Neesse 36 Management of Pancreatic Fistula in Acute Pancreatitis 300 Marta Sandini, Thilo Hackert, and Markus W. Büchler 37 Long- Term Outcome After Acute Pancreatitis 306 Christin Tjaden and Thilo Hackert Section 4 Chronic Pancreatitis 315 38 Definition and Classification of Chronic Pancreatitis 317 David C.
Whitcomb 39 Molecular Understanding of Chronic Pancreatitis 326 Bomi Lee, Monique T. Barakat, and Sohail Z. Husain 40 Natural History of Recurrent Acute and Chronic Pancreatitis 334 Rohit Das, Jorge D. Machicado, and Dhiraj Yadav 41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum 344 Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland 42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 349 Georg Beyer, Markus M. Lerch, and Julia Mayerle 43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis 357 Atsushi Irisawa and Akira Yamamiya 44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer 366 J. Enrique Domínguez- Muñoz, Julio Iglesias- García, José Lariño- Noia, and Daniel de la Iglesia- García 45 Hereditary Pancreatitis and Complex Genetic Causes 375 Celeste Shelton Ohlsen and David C. Whitcomb 46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 383 Shailesh V. Shrikhande and Savio G.
Barreto 47 CFTR- Associated Pancreatic Disease 390 Chee Y. Ooi and Aliye Uc 48 Alcohol and Smoking in Chronic Pancreatitis 396 Atsushi Masamune, Kazuhiro Kikuta, and Kiyoshi Kume 49 Idiopathic and Rare Causes of Chronic Pancreatitis 404 Morihisa Hirota and Tooru Shimosegawa 50 Early Chronic Pancreatitis 412 Kazuhiro Kikuta and Atsushi Masamune 51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head 418 Ulrich F. Wellner, Kim C. Honselmann, and Tobias Keck 52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications 424 Xiaodong Tian, Xiaochao Guo, and Yinmo Yang 53 Nutritional Evaluation and Support: An Overview 430 Sinead N. Duggan and Stephen J. O''Keefe 54 Exocrine Pancreatic Insufficiency 436 Chris E. Forsmark 55 Bone Disease in Chronic Pancreatitis 442 Sinead N. Duggan 56 Diabetes from Exocrine Pancreatic Disease 445 Nao Fujimori, Tetsuhide Ito, and Yoshihiro Ogawa 57 Oxidative Stress and Antioxidants in Chronic Pancreatitis 451 Soumya Jagannath Mahapatra and Pramod Kumar Garg 58 Pain Mechanisms in Chronic Pancreatitis 460 Pierluigi Di Sebastiano, Fabio Francesco di Mola, Tommaso Grottola, and Rossana Percario 59 Pain Management in Chronic Pancreatitis 467 Louise Kuhlmann, Søren S.
Olesen, and Asbjørn M. Drewes 60 Adjunctive Therapy in Chronic Pancreatitis 474 Anna Evans Phillips 61 Pancreatic Cancer Risks in Chronic Pancreatitis 480 Patrick Maisonneuve and Albert B. Lowenfels 62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 486 Jörg Schirra, Simon Sirtl MD, Markus M. Lerch, and Julia Mayerle 63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations 496 Faik G. Uzunoglu and Jakob R. Izbicki 64 Pancreatic Drainage Procedures: Techniques and Results 501 Ulrich F. Wellner, Dirk Bausch, and Tobias Keck 65 Duodenum- Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results 506 Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl 66 Total Pancreatectomy with Islet Autotransplant 515 Greg Beilman, Zachary Bergman, and Melena Bellin 67 Minimally Invasive Surgical Management of Chronic Pancreatitis 523 Gilbert Z.
Murimwa, Herbert J. Zeh III, and Matthew R. Porembka Section 5 Autoimmune Pancreatitis 533 68 Epidemiology of Autoimmune Pancreatitis 535 Terumi Kamisawa 69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis 540 Yoh Zen 70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 546 Tooru Shimosegawa 71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis 554 Nicolò de Pretis and Luca Frulloni 72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis 561 Tooru Shimosegawa 73 Laboratory Diagnosis of Autoimmune Pancreatitis 568 J- Matthias Löhr and Miroslav Vujasinovic 74 What is the Evidence Measuring Immune Markers 573 Shigeyuki Kawa, Takayuki Watanabe, and Norihiro Ashihara 75 Autoimmune Pancreatitis and IgG4- Related Disease.