Stephen Marks , MD MSc MRCP DCH FRCPCH is a Consultant Paediatric Nephrologist and Clinical Lead for renal transplantation at Great Ormond Street Hospital (GOSH). He is Professor of Paediatric Nephrology and Transplantation at University College London Great Ormond Street Institute of Child Health and Director of the NIHR GOSH Clinical Research Facility. Simon Blackburn MEd FRCS(paed.surg) FFST is a Consultant Neonatal and Paediatric Surgeon at Great Ormond Street Hospital where he is also Co-Director of Education and the Learning Academy. Stephan Strobel, MD, PhD, MRCP(Hon), FRCP, FRCPCH, is an Emeritus Professor of Paediatrics and Clinical Immunology, University of Plymouth and Honorary Professor of Paediatrics and Clinical Immunology, University College London Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, UK.