Introduction 1 Insulin: Basic Physiology and Pharmacology 3 Available Insulin Products 7 Rapid-Acting Insulin 7 Short-Acting Insulin 10 Intermediate-Acting Insulin 11 Long-Acting Insulin 12 Insulin Glargine (U-100) 12 Insulin Detemir 13 Insulin Glargine (U-300) 13 Insulin Degludec (U-100; U-200) 14 U-500 Regular Insulin 15 Premixed Insulin Products 15 Insulin Administration and Use Considerations 19 Insulin Delivery Method 19 Vial and Syringe 22 Insulin Pens 22 Smart Connected Insulin Pens 23 Continuous Subcutaneous Insulin Infusion (CSII; Insulin Pump) 23 Injection Technique 25 Factors That May Affect Absorption 26 Insulin Storage 27 General Approaches and Recommendations for Insulin Use in People with Diabetes 29 Type 1 Diabetes 29 Glycemic Goals and Targets in People with Type 1 Diabetes 31 Insulin Initiation and Titration 32 Insulin-to-Carbohydrate (I:C) Ratios 33 Correction Doses 34 Ongoing Insulin Adjustment in T1D 35 Type 2 Diabetes 35 Sample Insulin Regimens 39 Two Injections per Day 39 Three Injections per Day 40 Four Injections per Day, Example 1 41 Four Injections per Day, Example 2 42 Troubleshooting Barriers to Insulin Use and Key Adverse Events 45 Barriers to Insulin Use in Type 2 Diabetes 45 Hypoglycemia 46 Hypoglycemia Unawareness 48 Weight Gain 48 Adjustments for Physical Activity 49 Education and Resources for People with Diabetes 51 Index 55.