In this issue of Critical Care Nursing Clinics, guest editor Dr. Melissa Nunn, Instructor of Clinical Nursing at LSU Health New Orleans School of Nursing, brings her considerable expertise to the topic of Pediatric Intensive Care Nursing. Top experts in the field present systematic, evidence-based processes for decision making and care, addressing topics such as palliative communication in the PICU; dialysis care in the PICU; caring for hematology/oncology emergencies in the PICU; nurse-led rounds in the PICU; asthma care protocol implementation in the PICU; and more. Contains 12 relevant, practice-oriented topics including acute pain management protocols in the PICU; kangaroo care implementation; unplanned extubations in the PICU; pediatric delirium screening in the ICU; battling alarm fatigue within the PICU; and more. Provides in-depth clinical reviews on pediatric intensive care nursing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.