Section 1: Universal definition of heart failure 1.1. Universal definition of heart failure, Andrew JS Coats, Biykem Bozkurt and Petar M. Seferovic Section 2: Epidemiology of heart failure 2.1. Epidemiology of heart failure, Amy Groenewegen, Ivan Milinkovi?, Arno W Hoes, Arend Mosterd, Frans H Rutten Section 3: Etiology of heart failure 3.1. Coronary artery disease, (Rocco Antonio Montone, Maurizio Volterrani, Jian Zhang and Filippo Crea 3.
2. Hypertension, Athanasios Manolis and Yuri Lopatin 3.3. Valvular heart disease, Ana Pardo Sanz, Ivan Milinkovic and Josep Zamorano 3.4.1. Genetic basis of cardiomyopathies, Thomas Thum, Stephane Heymans, and Johannes Backs 3.4.
2. Dilated and hypokinetic non-dilated cardiomyopathy, Petar M.Seferovic, Biykem Bozkurt, and Marija Polovina 3.4.3. Hypertrophic cardiomyopathy, Perry Elliott, Michel Noutsias and Aris Anastasakis 3.4.4.
Restrictive cardiomyopathy, Claudio Rapezzi, Alberto Aimo, Ales Linhart, and Andre Keren 3.4.5. Arrhythmogenic right ventricular cardiomyopathy, Cristina Basso, Hugh Calkins and Domenico Corrado 3.4.6. Peripartum cardiomyopathy, Karen Sliwa and Johann Bauersachs 3.4.
7. Takotsubo cardiomyopathy, Jelena Templin-Ghadri, Michael Würdinger, Johann Bauersachs, and Christian Templin 3.5. Myocarditis and pericarditis, Stephane Heymans, Arsen Risti?, Yehuda Adler, and Massimo Imazio 3.6. Congenital heart disease, Werner Budts and Jolien Roos-Hesselink 3.7. Endocrine and metabolic disorders, Martin Huelsmann, Jelena Seferovic and Francesco Cosentino 3.
8. Obesity, Lina Badimon, Stefan Anker and Stephan von Haehling 3.9. Cancer and cancer therapy, Alexander Lyon, Dimitrios Farmakis, Daniela Cardinale and Teresa Lopez Fernandez 3.10. Toxins (e.g. alcohol etc.
) and infections, Antonello Gavazzi, Maria Nunes, and Fausto Pinto Section 4: Prevention of heart failure 4.1. Prevention of heart failure, Massimo Piepoli, Maria Benedetta Matrone, Paul Dendale, and Shelley Zieroth Section 5: Pathophysiology of heart failure 5.1. Molecular and cellular mechanisms, (Junjie Xiao, Thomas Thum, Gianluigi Condorelli and Johannes Backs 5.2. Alterations in myocardial metabolism, Edoardo Bertero and Chistoph Maack 5.3.
Ventricular remodelling, Javier Diez Martinez and Hans-Peter Brunner La Rocca 5.4. Neurohormonal activation, Antoni Bayes Gennis and Faiez Zannad 5.5. Immune-mediated mechanisms, Urlich Hofmann, Stefan Frantz and Nikolaos Frangogiannis 5.6. Inflammation, oxidative stress and endothelial dysfunction, Stephane Heymans 5.7.
Alterations in peripheral circulation and renal function, Alterations in peripheral circulation and renal function ( 5.8. Systemic adaptations in metabolism and nutritive status, (Stephan von Haehling and Wolfram Doehner Section 6: Clinical phenotypes of chronic heart failure 6.1. HFrEF, Thomas Luscher, Petar Seferovic, and Brian Halliday 6.2. HFmrEF, Adrian Voors, Brenda Moura, Lars Lund and Carolyn Lam 6.3.
HFpEF, Rudolf De Boer, Burkert Pieske, and Barry Borlaug 6.4. Right heart failure, Thomas Luscher, Thomas M. Gorter, Susanna Price, Michael Gatzoulis and Anneline Te Riele Section 7: Chronic heart failure: diagnostic and prognostic assessment 7.1. Clinical assessment, Michel Komajda, Piotr Ponikowski, and Evgeny Shlyakhto 7.2. Biomarkers in diagnostic and prognostic assessment, Rudolf de Boer, Antioni Bayes Genis and James Januzzi 7.
3. Echocardiography, Philippe Debonnaire, Victoria Delgado, Thor Edvardsen, Bogdan Popescu, and Jeroen Bax 7.4. Nuclear medicine, Danilo Neglia and Alessia Gimelli 7.5. Cardiac computed tomography, Stephan Achenbach and Amina Rakisheva 7.6. Cardiac magnetic resonance, Anna Baritussio, Noor Sharrack, Sven Plein, and Chiara Bucciarelli-Bucci 7.
7. Cardiopulmonary exercise, Luca Moderato, Davide Lazzeroni, Stamatis Adamopoulos, Alain Cohen-Solal and Massimo Piepoli 7.8. Cardiac catheterization, invasive imaging and haemodynamic assessment, Christian Hamm, Brigit Assmus and Veselin Mitrovic Section 8: Chronic heart failure: pharmacological management 8.1. Angiotensin converting enzyme inhibitors, Roberto Ferrari, Gabriele Guardigli, and Biykem Bozkurt 8.2. Angiotensin I receptor blockers, Ileana L.
Pina and Magdy Abdelhamid 8.3. ARNI, Petar M. Seferovic, Michele Senni, Marija Polovina and Andrew JS Coats 8.4. Beta-blockers, Daniela Tomasoni, Marianna Adamo, Hiroyuki Tsutsui, and Marco Metra 8.5. Mineralocorticoid receptor agonists, Bertram Pitt, João Pedro Ferreira and Faiez Zannad 8.
6. Ivabradine, Michael Bohm and Michel Komajda 8.7. Vasodilators, Eftihia Polyzogopoulou, Maria Nikolaou, John Parissis and Alexandre Mebazaa 8.8. Digitalis glycosides, Udo Bavendiek and Johann Bauersachs 8.9. Diuretics, Jeroen Dauw, Stephen Gottlieb and Wifried Mullens 8.
10. Inotropes and inodilators, Jan Biegus, Piotr Ponikowski, and Christoph Maack 8.11. SGLT2 inhibitors, Petar M. Seferovic, Francesco Cosentino, Giuseppe Rosano and James Januzzi 8.12. Ancillary pharmacological treatment options, Stefan Agewall, Isabelle van Gelder, and Irene Savelieva 8.13.
New and emerging therapies, Giuseppe Rosano, Gerasimos Filippatos, and Randall Starling Section 9: Chronic heart failure: non-pharmacological management 9.1. Implantable cardioverter defibrillator, Gianluigi Savarese, Cecilia Linde and Kenneth Dickstein 9.2. Cardiac resynchronization therapy, Pieter Martens, Eva Goncalvesova, and Wilfried Mullens 9.3. Cardiac surgery, Felix Schoenrat, Franz-Josef Neumann, Miguel Sousa Uva and Volkmar Falk 9.4.
Valve interventions, Stefan Orwat, Stefan Anker and Helmut Baumgartner 9.5. Ancillary procedures, Andrew JS Coats, Piotr P Ponikowski, Maria-Rosa Costanzo and William T. Abraham 9.6. Cardiac rehabilitation, Maurizio Volterrani, Alain Cohen-Solal, Stamatis Adamopulos, Dimitris Miliopoulos, Ferdinando Iellamo, and Massimo Piepoli Section 10: Acute heart failure 10.1. Acute heart failure: diagnostic and prognostic assessment, Ovidiu Chioncel, Gerasimos Filippatos, Alexandre Mebazaa, Veli-Pekka Harjola, and Josep Masip 10.
2. Acute heart failure: management, Katerina Fountoulaki, John Parissis, Sean Collins, Mehmet Birhan Yilmaz, and Alexandre Mebazaa Section 11: Advanced heart failure 11.1. Advanced heart failure: assessment, Tuvia Ben Gal, Mariell Jessup, and Maria-Rosa Costanzo 11.2. Advanced heart failure: management, Daniela Tomasoni, Marianna Adamo, and Marco Metra 11.3. Mechanical circulatory support, Mandeep Mehra and Finn Gustafsson 11.
4. Heart transplantation, Davor Milicic, Mandeep Mehra, and Randall Starling 11.5. Palliative care and end-of-life management, Tiny Jaarsma, Donna Fitzsimons, Lisa Hjelmfors, Loreena Hill, Ekaterini Lambrinou, and Anna Strömberg Section 12: Comorbidities and clinical conditions 12.1. Chronic kidney disease: Clinical Aspects of Chronic Kidney Disease in Heart Failure, Pieter Martens and Hans-Peter Brunner-La Rocca 12.2. Dyskalaemia, Javed Butler, Wilfried Mullens and Kevin Damman and João Pedro Ferreira 12.
3. Chronic lung disease, Josep Masip, Karina Portillo and Mattia Arrigo 12.4. Ventilatory Abnormalities and Sleep Disordered Breathing, Piergiuseppe Agostoni, Elisabetta Salvioni, Maria Rosa Costanzo, and Andrew JS Coats 12.5. Pulmonary hypertension, Irene M. Lang and Stephan Rosenkranz 12.6.
Cardiac rhythm disorders, Silvia Priori, Alessandro Trancuccio, Alessia Chiara Latini, Carlo Arnò, Deni Kukavica, and Andrea Mazzanti 12.7. Management of atrial fibrillation in heart failure, Paulus Kirchhof, Andreas Metzner, Ruben Schleberger and Douglas Packer 12.8. Diabetes, metabolic syndrome and endocrine disorders, Giuseppe Rosano, Javed Butler, Petar M. Seferovi?, Jelena Seferovic and Francesco Cosentino 12.9. Systemic immune medicated diseases, Giacomo De Luca, Luca Moroni, Alessandro Tomelleri, R Marcolongo, Lorenzo Dagna, Alida LP Caforio, and Marco Matucci-Cerinic 12.
10. Liver and gut dysfunction, Yuri Lopatin and Gianluigi Savarese 12.11. Anaemia and iron deficiency, Ewa Jankowska, Piotr Ponikowski, and Stefan Anker 12.12. Depression and cognitive impairment, Wolfram Doehner, Cristiana Vitale, and Mehmet Birhan Yilmaz 12.13. Cancer, Alexander Lyon, Dimitrios Farmakis, Rudolf de Boer, and Yuri Belenkov 12.
14. Pregnancy, Johann Bauersachs, Denise Hilfiker-Kleiner and Karen Sliwa 12.15. Frailty, Ewa Jankowska, Cristiana Vitale and Dong-Ju Choi Section 13: Self-care and patient education 13.1. Self-care and patient education, Tiny Jaarsma, Loreena Hill, Ekaterini Lambrinou, Anna Stromberg, and Tina Hansen Section 14: Multidisciplinary approach to heart failure management 14.1. Multidisciplinary approach to heart failure management, Loreena Hill, Friedrich Koehler, Tiny Jaarsma, Marija Polovina, Katherine McCreary, and Andrew JS Coats Section 15: Clinical trial design and interpretation 15.
1. Clinical trial design and interpretation, Gianluigi Savarese, Marija Polovina and Gerasimos Filippatos Section 16: Digital health in heart failure 16.1. Digital health in heart failure, Arvind Singhal and Martin Cowie Section 17: Big data in heart failure 17.1. Big data in heart failure, Mamas Mamas and Dipak Kotecha Section 18: Telemedicine and remote monitoring 18.1. Telemedicine and remote monitoring, Tarek Bekfani, Friedrich Koehler and William T.
Abraham.