List of contributors vii Foreword xi 1 Introduction 1 Claire Richardson and Huw Golledge Part 1 Implementing the Three Rs in research using animals 3 2 The Three Rs 5 Adrian Smith and Jon Richmond 3 The design of animal experiments 23 Simon T. Bate and S. Clare Stanford 4 An introduction to laboratory animal genetics 40 Michelle Stewart and Sara Wells 5 Phenotyping of genetically modified mice 54 Jan-Bas Prins and Sara Wells 6 Brief introduction to welfare assessment: a ''toolbox'' of techniques 64 Jennifer Lofgren 7 Welfare and ''best practice'' in field studies of wildlife 84 Julie Lane and Robbie A. McDonald 8 Legislation and oversight of the conduct of research using animals: a global overview 101 Kathryn Bayne, Javier Guillen, Malcolm P. France and Timothy H. Morris 9 Planning, design and construction of the modern animal facility 122 Ken Applebee, Christopher Sear and Steven Cubitt 10 Environmental enrichment: animal welfare and scientific validity 137 Hanno Würbel and Janja Novak 11 Special housing arrangements 150 Mike Dennis 12 Transportation of laboratory animals 171 Sonja T. Chou, Donna Clemons, Nicolas Dudoignon, Guy Mulder and Aleksandar Popovic 13 Nutrition, feeding and animal welfare 191 Graham Tobin and Annette Schuhmacher 14 Attaining competence in the care of animals used in research 220 Bryan Howard and Marcel Gyger 15 The use of positive reinforcement training techniques to enhance the care and welfare oflaboratory and research animals 236 Gail Laule 16 3Rs considerations when using ageing animals in science 251 J. Norman Flynn, Linda Horan, Carl S.
Tucker, David Robb and Michael J.A. Wilkinson 17 Euthanasia and other fates for laboratory animals 268 Huw Golledge 18 Ethics review of animal research 281 I. Anna S. Olsson and Peter Sandøe Appendix 294 Penny Hawkins and Maggy Jennings Part 2 Species kept in the laboratory 297 Mammals 299 19 The laboratory opossum 301 John L. VandeBerg and Sarah Williams-Blangero 20 Tree Shrews 324 Eberhard Fuchs Rodentia and Lagomorpha 340 21 The laboratory mouse: Biology, behaviour, enrichment and welfare: first principles and realsolutions for laboratory mice 340 Kathleen R. Pritchett-Corning and Joseph P. Garner 22 The laboratory rat 379 Sietse F.
de Boer and Jaap M. Koolhaas 23 The laboratory gerbil 400 Elke Scheibler 24 The Syrian hamster 419 Christina Winnicker and K.R. Pritchett-Corning 25 Voles 430 Petra Kirsch 26 The naked mole-rat (Heterocephalus glaber) 442 Chris G. Faulkes Appendix A 459 27 The guinea pig 465 Sylvia Kaiser, Christine Krüger and Norbert Sachser 28 The laboratory rabbit 484 Lena Lidfors and Therese Edström Carnivora 506 29 The ferret 506 Maggie Lloyd 30 The laboratory dog 518 Laura Scullion Hall and Jackie Boxall 31 The domestic cat 546 Emma Desforges Ungulates 570 32 Pigs and minipigs 570 Adrian Zeltner and Henrik Duelund Pedersen 33 Cattle 596 Ute Weyer and Shellene Hurley 34 Sheep and goats 609 Colin L. Gilbert and Cathy M. Dwyer 35 The Horse 628 Heather Ewence and Fleur Whitlock Non-Human Primates 662 36 The mouse lemurs 662 Jennifer Wittkowski, Annette Klein, Annika Kollikowski, Marina Scheumann, Daniel Schmidtke, Elke Zimmermann and Ute Radespiel 37 Marmosets and tamarins 683 Hannah M. Buchanan-Smith 38 Capuchin monkeys 707 James R.
Anderson, Elisabetta Visalberghi and Arianna Manciocco 39 Old world monkeys 721 Jaco Bakker, Annet L. Louwerse, Marit K. Vernes and Jan A.M. Langermans Birds 739 40 The domestic fowl 741 Ian J.H. Duncan 41 The Japanese quail 762 Rusty Lansford and Kimberly M. Cheng 42 The zebra finch 787 Ruedi G.
Nager, Michael J.A. Wilkinson and Graham Law 43 Pigeons and doves 807 Stephen E.G. Lea, Anthony McGregor, Mark Haselgrove and Catriona M.E. Ryan 44 The European starling 824 Melissa Bateson 45 Corvids 839 Rachael Miller, Martina Schiestl and Nicola S. Clayton Reptiles and Amphibia 853 46 Terrestrial reptiles: lizards, snakes and tortoises 855 John E.
Cooper 47 An amphibian ''laboratory model'', Xenopus 881 Richard Tinsley Fish 905 48 Fishes 907 Sonia Rey Planellas and Carlos Garcia de Leaniz 49 Zebrafish 933 Carole Wilson Cephalopoda 957 50 Cephalopoda 959 Meghan Holst, Ryan B. Howard and Robyn J. Crook Decapoda 991 51 Decapod crustaceans 993 Robert W. Elwood and Ray W. Ingle Index 1012.