In this issue of Critical Care Clinics, guest editors Drs. Michelle Ng Gong and Gregory S. Martin bring their considerable expertise to the topic of COVID-19. Top experts in the field cover key topics such as ECMO in COVID-19, neurologic manifestations and sequelae in COVID-19, pediatric COVID-19, anti-viral and anti-inflammatory therapeutics in COVID-19, the critical care surge during COVID-19 and lessons for the future, and more. Contains 11 relevant, practice-oriented topics including post-acute sequelae of SARS CoV-2 infection; COVID-19 and renal failure; the role of acute thrombosis in COVID-19; COVID ARDS: different phenotype of ARDS or same diversity of phenotype in ARDS; COVID-19 in the critically ill pregnant patient; and more. Provides in-depth clinical reviews on COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.