PART I: BASIC CONSIDERATIONS Chapter 1 Evolution of Regenerative Medicine in Managing Chronic Pain Chapter 2 Principles of Evidence-Based Medicine Chapter 3 Documentation and Compliance in Regenerative Medicine Chapter 4 Biologics in Clinical Setting: Standardization and Collaboration Chapter 5 Principles of Fluoroscopy Imaging in Spine and Musculoskeletal Medicine Chapter 6 Principles of Ultrasound Imaging in Musculoskeletal Medicine Chapter 7 Platelet Rich Plasma Chapter 8 Bone Marrow Concentrate Chapter 9 Adipose Cells or Stromal Vascular Fraction Chapter 10 Non-Autologous Biologics Chapter 11 The Role of Exosomes in Regenerative Medicine Chapter 12 Prolotherapy Chapter 13 Platelet Rich Plasma, Bone Marrow Concentrate, and Adipose Mesenchymal Stem Cells: Hemo-analysis and Quality Control: What Does it All Mean? Chapter 14 Implications of Antithrombotic Therapy in Regenerative Medicine Chapter 15 Post Injection Therapy Management Chapter 16 Non-Opioid Pharmacotherapy for Musculoskeletal Disorders Chapter 17 Opioid Therapy for Musculoskeletal Disorders Chapter 18 Pathophysiology and Mechanisms of Chronic Musculoskeletal Pain PART II: REGENERATIVE MEDICINE IN MUSCULOSKELETAL PATHOLOGY Chapter 19 Shoulder and Related Joints, Ligaments, and Tendons Chapter 20 Elbow and Related Joints, Ligaments, and Tendons Chapter 21 Hip and Related Joints, Ligaments, and Tendons Chapter 22 Regenerative Medicine for Knee Osteoarthritis Chapter 23 Treatment of Knee Ligaments, Meniscus, and SubChondral Bone Disorders with Biologics Chapter 24 Ankle and Foot, and Related Joints, Ligaments and Tendons PART III: REGENERATIVE MEDICINE IN THE SPINE Chapter 25 Imaging of the Spine Chapter 26 Intradiscal Injections of Biologics Chapter 27 Epidural Administration of Platelet Rich Plasma and Stem Cells Chapter 28 Lumbar Facet Joints and Regenerative Medicine Chapter 29 Cervical Facet Joints and Regenerative Medicine Chapter 30 Thoracic Facet Joints and Regenerative Medicine Chapter 31 Regenerative Medicine for Sacroiliac Joint Dysfunction Chapter 32 Treatment of Low Back Pain with Mesenchymal Stem Cells: Chapter 33 Regenerative Therapy for Chronic Pelvic Pain Syndromes IV: MISCELLANEOUS APPLICATIONS Chapter 34 Interstitial Cystitis and Stem Cell Therapy Chapter 35 Stem Cell Therapies for Neurological Disorders Chapter 36 Regulatory Aspects of Regenerative Therapy and Stem Cell Therapy: Current Perspectives Chapter 37 Ethical and Policy Issues in Practices of Regenerative Medicine for the Treatment of Chronic Pain Chapter 38 The Role of Regenerative Medicine in COVID-19 Pandemic and Long Covid PART VI: PRACTICE MANAGEMENT Chapter 39 Guidelines in Regenerative Medicine.