Foreword by Steve Edelman Introduction and Preface by Andre J Krentz Section 1: Normal Physiology: Insulin Secretion and Insulin Action 1. Insulin Biosynthesis and Release by Gabriela da Silva Xavier 2. Classic Metabolic Actions of Insulin in Humans by Andrew J Krentz 3. Non-classic Effects of Insulin by George King Section 2a: Role of Insulin in Human Disease 4. Type 1 Diabetes Pathogenesis: Lessons Learned and Questions that Remain by Adebola Matthew Giwa, Abdel Hamad, Zahra Omidian, Angela Yang, Neha Majety, Tiffany Jackson, Kusuma Ananth, Mohanraj Sadasivam, Marjan Behzadirad, Thomas Donner and Rizwan Ahmed 5. Insulin Therapy - A Century of Progress by Geremia Bolli 6. Treatment and Prevention of Type 1 Diabetes in the 21st Century by Jay S Skylar, David Baidal, and J Sosenko 7. Differentiation of Diabetes by Pathophysiology: A Focus on Insulin Deficiency vs Insulin Resistance by Adrian Heald Section 2b: Syndromes of Insulin Excess 8.

Congenital Hyperinsulinism by Katherine Lord and Diva D De Leon 9. Hypoglycemic Disorders in Adults by Adrian Vella and Maheswaran Dhanasekaran Section 2c: Insulin Resistance in Human Disease 10. Obesity and Insulin Resistance: Pathophysiology and Principles of Therapy by Rita Basu 11. The Cardiometabolic Syndrome and Vascular Disease: Pivotal Role of Insulin by Michael D Shapiro, Trevor Caldarera, and Jordan Tannenbaum 12. Insulin, IGF-1, and Cancer: Pathogenic Considerations and Therapeutic Opportunities by John Vincent Reynolds and Jessie Andrea Elliott 13. Insulin and Neurodegenerative Diseases by Heather A Ferris 14. Non-pharmacological, Pharmacological, and Surgical Options for Obesity-related Cardiometabolic Disorders: Metabolic and Clinical Impact by Alexander Dimitri Miras, Mariana Abdel-Malek, and Darmiga Thayabaran 15. Syndromes of Severe Insulin Resistance: Lessons from Nature by Andrew J Krentz.