Part I: Development and cancer: basic concepts.- Chapter 1: Introductory chapter by Sorlie and Clarke.- Chapter 2: Embryonic mammary gland morphogenesis.- Chapter 3: Breast morphogenesis: from normal development to cancer.- Chapter 4: Single-Cell Analysis in the Mouse and Human Mammary Gland.- Part II: Development and cancer: model systems and approaches.- Chapter 5: Recording lineage history with cellular barcodes in the mammary epithelium and in breast cancer.- Chapter 6: Models for studying ductal carcinoma in situ progression.
- Chapter 7: Patient-derived xenografts of breast cancer.- Chapter 8: Rat Models of Breast Cancer.- Part III: Development and cancer: cells of origin and heterogeneity.- Chapter 9: Cells of origin of breast cancer and intertumoral heterogeneity.- Chapter 10: Mechanisms of regulation of cell fate in breast development and cancer.- Chapter 11: Classification of breast cancer through the perspective of cell identity models.- Part IV: Cellular and molecular basis.- Chapter 12: The Microenvironment in DCIS and its Role in Disease Progression.
- Chapter 13: Molecular basis of breast tumor heterogeneity.- Chapter 14: E-cadherin-mediated cell-cell adhesion and invasive lobular breast cancer.- Part V: Signalling pathways.- Chapter 15: Hormone signaling in breast development and cancer.- Chapter 16: RANK/RANKL signaling pathway in breast development and cancer.- Chapter 17: Metabolic Reprogramming and Adaption in Breast Cancer Progression and Metastasis.- Part VI: Metastasis and immunity.- Chapter 18: Microenvironmental regulation of dormancy in breast cancer metastasis: "An ally that changes allegiances".
- Chapter 19: The Roles of Myeloid Cells in Breast Cancer Progression.- Chapter 20: Immune microenvironment in breast cancer metastasis.- Part VII: Subtypes, treatment and resistance.- Chapter 21: Clinical Implications of Breast Cancer Intrinsic Subtypes.- Chapter 22: Targeting Estrogen Receptor signalling in breast cancer therapy.- Chapter 23: CDK4/6 inhibitor resistance in ER+ breast cancer.- Chapter 24: HER2-positive breast cancer treatment and resistance.