A three-in-one foundational text that comprehensively documents the known effects of chemical mixtures on the human body; presents a plausible framework for beginning to understand and predict their effects; and recommends how to limit and regulate the release of mixtures into the environment. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists. A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures. New and updated material comprises over 30% of this timely new edition. The second edition has three new chapters; children's toxicology, Nanoloxicology and the toxicology of global warming. In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In Part I, the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion.

Part II examines the sources of the chemicals discussed, looking at air and water pollution, indoor air environments, food additives, pharmaceuticals, etc. Part III, with numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures and how to limit exposure to mixtures in the products we use and on how to limit release of mixtures Into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professional. Addressing many inadequately understood illnesses and conditions such as asthma, infertility, cancer and other unexplained environmentally induced diseases, it will also be of interest to emergency room physicians, internists and other health professionals, environmental scientists, industrial hygienists, formulators of chemical products, and lawyers. A must for every college, university and research laboratory library. This book is a recommended text for toxicology, medicinal chemistry and industrial hygiene courses. Book jacket.