Dedication Epigraph List of figures and tables Figures Tables Acknowledgments About the editor About the contributors Introduction Motivation: Organization of the chapters Audience 1. Electrochemotherapy - A novel cancer treatment Abstract: 1.1 Why electrochemotherapy? 1.2 References 2. Clinical electrochemotherapy for chest wall recurrence from breast cancer Abstract: 2.1 Introduction 2.2 Scope of the problem 2.3 Treatment options for chest wall recurrence 2.
4 Clinical experience with electrochemotherapy 2.5 Electrochemotherapy: the engineer''s point of view 2.6 Conclusions and perspectives 2.7 Acknowledgments 2.8 References 3. Clinical electrochemotherapy for advanced superficial melanoma Abstract: 3.1 Introduction 3.2 Therapeutic options in advanced melanoma 3.
3 Clinical experience with electrochemotherapy 3.4 Conclusions and perspectives 3.5 References 4. Low and high voltage electrochemotherapy for breast cancer: an in vitro model study Abstract: 4.1 Introduction 4.2 Anatomy of the breast and its cancer 4.3 Drug delivery issues 4.4 Chemotherapy issues 4.
5 Common adverse effects of anticancer drugs 4.6 Anticancer drug resistance 4.7 Electroporation and electrochemotherapy 4.8 Materials and methods 4.9 Results and discussion 4.10 Conclusions 4.11 Acknowledgments 4.12 References 5.
Why electroporation is a useful technique for cancer treatments Abstract: 5.1 Introduction 5.2 What is electroporation (EP)? 5.3 Irreversible electroporation (IRE) 5.4 Electrochemotherapy (ECT) 5.5 Example of a hydrophilic agent used with electrochemotherapy 5.6 Local delivery by intratumoral injection versus systemic administration in EP 5.7 Prerequisites for effective ECT 5.
8 ECT can overcome multidrug resistance 5.9 Intense nanosecond pulsed electric fields (nsPEFs) 5.10 Electroporation therapies can produce a reduction in blood flow to tumors 5.11 Properties of solid tumors 5.12 Why do tumors have increased susceptibility to (EP) permeabilizing pulses, compared to that of normal tissue? 5.13 Membrane composition and mineral concentrations of cancer cells affect the electrical properties 5.14 Oxygen levels vary in solid tumors 5.15 Glycolysis and pH 5.
16 Conclusions 5.17 References 6. Electrically-enhanced proliferation control of cancer-stem-cells-like adult human mesenchymal stem cells - a novel modality of treatment Abstract: 6.1 Introduction - stem cells 6.2 Mesenchymal stem cells 6.3 Cancer and cancer stem cells 6.4 Electrochemotherapy 6.5 In-vitro study of ECT on MSC 6.
6 Materials and methods 6.7 Results and analyses 6.8 Discussion and conclusions 6.9 Future directions 6.10 Acknowledgments 6.11 References 7. An in vitro study of electroporation of leukemia and cervical cancer cells Abstract: 7.1 Introduction 7.
2 Materials and methods 7.3 Results and analysis 7.4 Conclusions 7.5 Acknowledgments 7.6 References 8. Low voltage nanosecond electroporation for breast cancer treatment: an in vitro study Abstract: 8.1 Introduction 8.2 Materials and methods 8.
3 Results and analysis 8.4 Discussion and conclusions 8.5 Acknowledgment 8.6 References 9. Low and high voltage electroporation of in vitro human ovarian adenocarcinoma cells Abstract: 9.1 Introduction 9.2 Materials and methods 9.3 Results and analysis 9.
4 Discussion and summary 9.5 Acknowledgments 9.6 References 10. Irreversible electroporation: a drug-free cancer treatment Abstract: 10.1 Introduction 10.2 Materials and methods 10.3 Results and analyses 10.4 Discussion and conclusions 10.
5 Acknowledgments 10.6 References 11. Targeted delivery of siRNA and other difficult to transfect molecules using electroporation: current status and future scope Abstract: 11.1 Introduction 11.2 siRNA - a potential therapeutic tool for cancer treatment 11.3 siRNA-Gene targets in Cancer 11.4 Delivery of siRNA 11.5 Electroporation-based siRNA delivery 11.
6 Summary and Future Scope 11.7 References 12. Electric field distribution study of breast tumors Abstract: 12.1 Introduction 12.2 Electric field concepts 12.3 Electrical properties of cells 12.4 Finite element modeling 12.5 Electric field intensity used in clinical electrochemotherapy 12.
6 Electrodes used 12.7 Thermal effects of electroporation 12.8 Simulation 12.9 Breast modeling 12.10 Results and discussion 12.11 Conclusions 12.12 References Index.