Chiral Separation Techniques : A Practical Approach
Chiral Separation Techniques : A Practical Approach
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Author(s): Subramanian, Ganapathy
ISBN No.: 9783527315093
Pages: 641
Year: 200612
Format: Trade Cloth (Hard Cover)
Price: $ 453.95
Status: Out Of Print

Preface.List of Contributors.1 Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases (Thomas E. Beesley and J.T. Lee).1.1 Introduction.


1.2 Structural Characteristics of Macrocyclic Glycopeptide CSPs.1.3 Enantioselectivity as a Function of Molecular Recognition.1.4 Complementary Effects.1.5 Method Development.


1.6 Optimization Procedures.1.7 Amino Acid and Peptide Analysis.1.8 Conclusion.Acknowledgments.References.


2 Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis (Imran Ali and Hassan Y. Aboul-Enein).2.1 Introduction.2.2 Structures of Polysaccharide Chiral Selectors.2.3 Properties of Polysaccharide CSPs.


2.4 Applications.2.5 Optimization of Chiral Separations.2.6 Chiral Recognition Mechanisms.2.7 Chiral Separation by Sub- and Supercritical Fluid Chromatography.


2.8 Chiral Separation by Capillary Electrochromatography.2.9 Chiral Separation by Thin-layer Chromatography.2.10 Chiral Separation by Capillary Electrophoresis.2.11 Conclusion.


References.3 Analytical and Preparative Potential of Immobilized Polysaccharide-derived Chiral Stationary Phases (Tong Zhang and Pilar Franco).3.1 Introduction.3.2 Scope of Immobilized Polysaccharide-derived CSPs.3.3 Beneficial Characteristics of Immobilized Polysaccharide-derived CSPs.


3.4 Method Development on Immobilized Polysaccharide-derived CSPs.3.5 Regeneration of Immobilized CSPs - Why, How and When.3.6 Conclusions and Perspectives.References.4 Chiral Separations Using Supercritical Fluid Chromatography (Karen W.


Phinney and Rodger W. Stringham).4.1 Introduction.4.2 Overview of SFC.4.3 Chiral Stationary Phases in SFC.


4.4 Mobile Phase Effects in SFC.4.5 Preparative-scale Separations.References.5 Chiral Separation by Ligand Exchange (Gerald G??bitz and Martin G. Schmid).5.


1 Introduction.5.2 Chiral Ligand-exchange Chromatography.5.3 Complexation Gas Chromatography.5.4 LE-Electromigration Techniques.List of Abbreviations.


References.6 Advances in Simulated Moving Bed Chromatographic Separations (Pedro S?! Gomes, Mirjana Minceva, Lu?-s S. Pais, and Al?-rio E. Rodrigues).6.1 Introduction.6.2 Modeling Strategies.


6.3 Simulation.6.4 Novel SMB Configurations.6.5 Improvements in Operation Conditions Evaluation (Separation Volume Method).6.6 Conclusions.


References.7 Less Common Applications of Enantioselective HPLC Using the SMB Technology in the Pharmaceutical Industry (Stefanie Abel and Markus Juza).7.1 Introduction - From an Emerging Technology to a Classical Unit Operation.7.2 Unbalanced Separations and Multi-component Separations Using SMB.7.3 Unusual Isotherms and Adsorption Behavior.


7.4 Applications of Various Column Configurations.7.5 Application of Solvent Gradients.7.6 Chemistry and Racemization.7.7 Future Developments.


7.8 Conclusion.

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