The mysterious Ezekiel Sims re-enters Peter Parker's life with a shocking new explanation as to how the web-slinging hero was granted his amazing spider-powers. But there's little time to ponder this mystery, as the ancient being Shathra has decided that Spider-Man is her prey! Can Peter unleash the spider inside to destroy this voracious predator? Next, the origin of Ezekiel's own spider-powers are revealed, along with the blood debt that must be paid for them. But which spider-totem will pay the price? Reprinting The Amazing Spider-Man (Vol. 3) #46-50 and #506-508.