Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders
Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders
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Author(s): Smith, Moyra
ISBN No.: 9780128219133
Pages: 306
Year: 202104
Format: Trade Paper
Price: $ 210.36
Dispatch delay: Dispatched between 7 to 15 days
Status: Available

Section I Brain, early development cortices, architecture, cell types, connectivity, networks 1. Early brain development; 2. Development and evolution of cerebral and cerebellar cortex; 3. White matter development and maturation of connections; 4. Brain size; 5. Emergence of functional architecture; 6. Architectonic mapping beyond Brodman; 7. Neuronal cells organization according to transcription; 8.


Association cortices; 9. Cell maps neuronal cell types, classification; 10. Development of network hubs; 11. Functional and structural connectivity; 12. Myelo-architecture; 13. Connectome and network theory; 14. Hubs modules nodes; 15. Microstructure connectomics; 16.


Dendrites, dendritic spines, spine patterns; 17. Networks; 18. Distinct metabolic and cytoarchitecture and increased dendritic density in hubs; 19. Oligodendrocytes and astrocytes Section II Neurotransmitters, Neuromodulators. Synapses 20. Neurotransmitters and neuroreceptors, neuromodulators; 21. Signalling downstream of receptors; 22. Synapses, structure, diversity; 23.


Post-synaptic interactome; 24. Dendrites and transmission; 25. Ion channels and channel dynamics; 26. Lipids and synaptic function Section III. Brain Mapping 27. Mapping structural connections forms of imaging; 28. Functional connectivity and brain metabolic activity; 29. Receptor autoradiography; 30.


NIH Connectome project Section IV. Brain Plasticity 31. Neuroplasticity; 32. Brain derived neurotrophic factors; 33. Dendritic spine dynamics and synaptic plasticity; 34. Oligodendrocyte lineage and brain plasticity; 35. Mitochondria and brain energy; 36. Metabolism and circadian rhythm Section V.


Gene Expression and Regulation in Brain and Epigenetics 37. Signalling pathways; 38. Gene transcription; 39. Epigenetics and regulation of expression; 40. 3D genome and regulation chromatin modifications and dynamics; 41. Epigenetics, environmental factors; 42. Genomic imprinting and defects potentially impacting development; 43. Genomic regulatory elements and transcription Section VI.


Neuroimmunology 44. Neuro-immunology past present and future; 45. Brain immune system; 46. Micro glia and functions related to immune functions; 47. Cytokines and neuromodulators; 48. Defined neuroimmune diseases Section VII. Neurodevelopmental, Neurocognitive and Behavioral Disorders 49. ICD 11 DSM 6 Classification of Pediatric disorders; 50.


Neuronal activity post-natal neurogenesis and gliogenesis; 51. Genomic copy number variants in autism and in neurocognitive disorders Genotype phenotype correlation i 52. copy number disorders; 53. Early brain and behavior and development in autism; 54. Functional brain connectome in autism; 55. Idiopathic autism, studies in derived in pluripotent stem cell derived neurons; 56. Gene sequence studies and genome wide association studies in autism; 57. Autism genetic and phenotypic heterogeneity; 58.


Specific genetic defects and Syndromic autism spectrum disorders; 59. Non-syndromic autism rare variants; 60. Common variants that impact risk in autism spectrum disorders; 61. Beyond the exome Noncoding genome and enhancers in neurodevelopment; 62. Regulatory elements in neurodevelopmental disorders; 63. Chromosome 22q11.2 microdeletion and microduplication and consequent disorders; 64. Attention deficit disorders risk variants; 65.


Cross over in neurobehavioral disorders; 66. Intellectual disability inborn errors of metabolism impacting risk nuclear and mitochondrial defects; 67. Therapeutic advances Section VIII Psychiatric diseases 68. DSM and ICD classifications on basis of clinical manifestations; 69. Architectural and cellular elements in psychiatric disorders; 70. Connectome disruptions in psychiatric diseases; 71. Shared heritability in psychiatric disorders; 72. NIH brain initiative; 73.


Future of Psychiatry; 74. Treatment of Psychiatric disorders medications, Neurobehavioral therapy; 75. Microbiome and potential gut brain interactions; 76. Neuromodulation techniques; 77. Ethics and Neuroethics in the Brain Initiative Section IX Health and Wellbeing 78. Environmental factors and epigenetics; 79. Nutritional Deficiencies; 80. Environment and Stress systems involved in stress responses; 81.


Social Cognition; 82. Ecosystem Ecotherapy; 83. Enhancing Neuroplasticity, promoting Resilience Section X Brain and Mind 84. Concepts and Ideas; 85. Environment, Learning, Experience; 86. Cultures and Societies.


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