Organic Synthesis

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Author(s):	Smith, Michael
ISBN No.:	9780443158674
Pages:	1,100
Year:	202410
Format:	Trade Paper
Price:	$ 220.80
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CHAPTER???? 1? Retrosynthesis, Stereochemistry, And Conformations? ? 1.1. Introduction? 1.2. The Disconnection Protocol? 1.3. Bond Proximity and Implications for Chemical Reactions? 1.4.

Stereochemistry? 1.5. Conformations? 1.6.? Conclusion? HOMEWORK ? CHAPTER???? 2? Acids And Bases and Addition Reactions? ? 2.1. Introduction? 2.2.

? Brønsted-Lowry Acids and Bases? 2.3.??? Lewis Acids? 2.4?? Hard-Soft Acid-Base Theory? 2.5.? Acid-Base Reactions in Organic Chemistry? 2.5. Addition Reactions? 2.

6.?? Conclusion? HOMEWORK ???? CHAPTER???? 3? Functional Group Exchange Reactions.?? Aliphatic and Aromatic Substitution,?? and Elimination Reactions? ? 3.1. Introduction? 3.2.?? Aliphatic Substitution Reactions?? 3.3.

?? Heteroatom-Stabilized Carbocations? 3.4.? Substitution by Halogen?? 3.5. Elimination Reactions? 3.6.? Characteristics Of Substitution and Elimination Reactions? 3.7.

? Syn-Elimination Reactions? 3.8.? 1,3-Elimination (Decarboxylation)? 3.9.? 1,3-Elimination (Grob Fragmentation)? 3.10.? Aromatic Substitution? HOMEWORK ? CHAPTER???? 4? Acids, Bases, And Functional Group Exchange Reactions.?? Acyl Addition and Acyl Substitution? ? 4.

1. Introduction? 4.2.? Nucleophilic Acyl Addition and Substitution?? 4.3.? Conjugate Addition? 4.4.? Functional Group Manipulation by Rearrangement? 4.

5.? Macrocyclic Compounds? 4.6.?? Conclusion? HOMEWORK ? CHAPTER???? 5? Functional Groups Exchange Reactions.??? Protecting Groups? ? 5.1. Introduction? 5.2.

? When Are Protecting Groups Needed?? 5.3.? Protecting Groups for Alcohols, Carbonyls, And Amines? 5.4.? Conclusion? HOMEWORK ? CHAPTER???? 6? Functional Group Exchange Reactions. Oxidations? ? 6.1. Introduction? 6.

2.? Alcohols To Carbonyls (CH-OH ® C=O)? 6.3.?? Formation of Phenols and Quinones? 6.4.? Oxidation of Alkenes to Epoxides? 6.5.? Conversion of Alkenes to Diols (C=C ® CHOH-CHOH)? 6.

6.? Baeyer-Villiger Oxidation (RCOR'' ® RCO2R'')? 6.7.? Oxidative Bond Cleavage (C=C ® C=O?? +?? O=C)? 6.8. Oxidation Of Alkyl or Alkenyl Fragments (CH ® C=O or C--OH)? 6.9.? Oxidation Of Sulfur, Selenium, And Nitrogen? 6.

10.? Conclusion? HOMEWORK ? CHAPTER???? 7? Functional Group Exchange Reactions. Reductions? ? 7.1. Introduction? 7.2. The Nature of Hydride Reducing Agents? 7.3.

? Borane and Aluminum Hydride?? 7.4.? Sodium Borohydride? 7.5.?? Alternative Metal Borohydrides (Li, Zn, Ce)? 7.6.? Lithium Aluminum Hydride? 7.7.

? Hydride Reducing Agents with Electron-Releasing Groups? 7.8.? Hydride Reducing Agents with Electron-Withdrawing Groups? 7.9. Stereoselectivity In Reductions?? 7.10.? Catalytic Hydrogenation? 7.11.

? Dissolving Metal Reductions?? 7.12.? Nonmetallic Reducing Agents?? 7.13. Conclusion? HOMEWORK ? CHAPTER???? 8? SYNTHETIC STRATEGIES? ? 8.1. Introduction? 8.2.

? Target Selection? 8.3.? Retrosynthesis? 8.4.? Synthetic Strategies? 8.5.? The Strategic Bond Approach? 8.6.

? Strategic Bonds in Rings? 8.7.? Selected Synthetic Strategies: Ra current popular target? 8.8.? Biomimetic Approach to Retrosynthesis? 8.9.? The Chiral Template Approach? 8.10.

?? Degradation Techniques as a Tool for Retrosynthesis? 8.11.? Computer Generated Strategies? 8.12.? Conclusion? HOMEWORK ? CHAPTER???? 9? Functional Group Exchange Reactions.? Hydroboration? ? 9.1.? Introduction? 9.

2.? Preparation of Alkyl Boranes? 9.3.? Preparation of Alkenylboranes? 9.4.? Formation of Oxygen-Containing Functional Groups? 9.5.? Other Functional Group Exchange Reactions? 9.

6.? Conclusion? HOMEWORK? CHAPTER???? 10? Functional Group Exchange Reactions.?? Selectivity?? ? 10.1. Introduction? 10.2.? Stereocontrol In Acyclic Systems? 10.3.

? Stereocontrol In Cyclic Systems? 10.4.? Neighboring Group Effects and Chelation Effects? 10.5.? Acyclic Stereocontrol Via Cyclic Precursors? 10.6.? Baldwin''s Rules for Ring Closure? 10.7.

? Conclusion? HOMEWORK ? CHAPTER???? 11? Carbon-Carbon Bond-Forming Reactions.?? Cyanide, Alkyne Anions, Grignard Reagents, and Organolithium Reagents? ? 11.1.? Introduction? 11.2.? Cyanide? 11.3.? Alkyne Anions (R-CºC:-)? 11.

4??? Grignard Reagents (C--Mg)? 11.5. Grignard Reagents. Reduction, Organocerium Reagents, and Enolization? 11.6.? Organolithium Reagents (C--Li)? 11.7.? Conclusion? HOMEWORK ? CHAPTER???? 12? Carbon-Carbon Bond-Forming Reactions.

?? Stabilized Carbanions, Organocuprates, and Ylids? ? 12.1.? Introduction? 12.2.? Sulfur Stabilized Carbanions and Umpolung? 12.3.?? Organocopper Reagents (C--Cu)? 12.4.

? Phenolic Carbanions? 12.5.? Ylids? 12.6.? Transition Metal Olefination Reagents? 12.7.? Silane Reagents? 12.8.

? Conclusion? HOMEWORK ? CHAPTER??? 13? Carbon-Carbon Bond-Forming Reactions.?? Enolate Anions? ? 13.1. Introduction? 13.2.? Formation Of Enolate Anions? 13.3.? Reactions Of Enolate Anions with Electrophiles? 13.

4.? Enolate Condensation Reactions? 13.5.? Stereoselective Enolate Reactions? 13.6.?? Enamines? 13.7.? Michael Addition and Related Reactions? 13.

8.? Enolate Reactions of a Halo Carbonyl Derivatives? HOMEWORK ? CHAPTER???? 14? Pericyclic Reactions.? The Diels-Alder Reaction? ? 14.1.? Introduction? 14.2.? Frontier Molecular Orbital Theory? 14.3.

? HOMO, LUMO Energies and Orbital Coefficients? 14.4.? Allowed and Forbidden Reactions? 14.5.? The Diels-Alder Reaction? 14.6.? Rate Enhancement in Diels-Alder Reactions? 14.7.

?? Intramolecular Diels-Alder Reactions? 14.8.? Inverse Electron Demand and The Retro Diels-Alder Reactions? 14.9.? Heteroatom Diels-Alder Reactions? 14.10.? Enantioselective Diels-Alder Reactions? 14.11.

? Conclusion? HOMEWORK 1516? CHAPTER???? 15? Pericyclic Reactions: [m+n]-Cycloadditions, Sigmatropic Rearrangements,?? Electrocyclic and Ene Reactions? ? 15.1.? Introduction? 15.2.???? [2+2]-Cycloaddition Reactions? 15.3.???? Electrocyclic Reactions? 15.4.

???? [3+2]-Cycloaddition Reactions? 15.5.???? (m+n]-Cycloaddition Reactions? 15.5.? Sigmatropic Rearrangements? 15.6.? The Ene Reaction? 15.7.

? Conclusion? HOMEWORK ? CHAPTER???? 16? Carbon-Carbon Bond-Forming Reactions.?? Carbocation and Oxocarbenium Ion Intermediates? ? 16.1. Introduction? 16.2.? Carbocations?? 16.3.? Carbocations and Carbon-Carbon Bond Forming Reactions?? 16.

4.? Friedel-Crafts Reactions? 16.5.? Friedel-Crafts Reactions:? Formation of Heteroatom-Containing Derivatives? 16.6.? Conclusion? HOMEWORK ? CHAPTER???? 17? Formation Of Carbon-Carbon Bonds Via Radicals and Carbenes? ? 17.1.? Introduction? 17.

2.? Structure Of Radicals? 17.3.? Formation Of Radicals by Thermolysis? 17.4.? Photochemical Formation of Radicals? 17.5.? Reactions Of Free Radicals? 17.

6.? Intermolecular Radical Reactions? 17.7.? Intramolecular Radical Reactions (Radical Cyclization)? 17.8.???? Metal-Induced Radical Reactions? 17.9.???? Carbenes And Carbenoids? 17.

10.? Conclusion? HOMEWORK? CHAPTER???? 18? Metal-Mediated, Carbon-Carbon Bond-Forming Reactions? ? 18.1. Introduction? 18.2.? Copper-Catalyzed Coupling Reactions? 18.3. p-Allyl Palladium Complexes? 18.

4.? Named Palladium-Catalyzed Coupling Reactions? 18.5.? p-Allyl Nickel Complexes? 18.6.? Metathesis Reactions? 18.7. Pauson-Khand Reaction? 18.

8.? Organometallic Compounds as Carbanionic Reagents? 18.9.? Electrophilic Iron Complexes? 18.10.? Conclusion? HOMEWORK ? CHAPTER???? 19? Combinatorial And Process Chemistry? ? 19.1. Combinatorial Chemistry? 19.

2. Process Chemistry? 19.3.?? Continuous Flow Synthesis? 19.4.? Conclusion? HOMEWORK ? ? General Index ? Disconnection Index?.

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