Introduction Risk Assessment Paradigm from the 1983 Redbook-"Risk Assessment in the Federal Government: Managing the Process" Risk Assessment Guidance for Superfund (RAGS) Part A 1989 The Interface of Risk Assessment and Risk Management History of Risk Assessment in the US from 1990 to 2010 Risk Communication and Stakeholder Participation Risk Assessment Policy and the Role of Science How Risk is Perceived and Expressed Actuarial Risk Predicted Risk Perceived Risk Risk Estimates for Regulation Uncertainty in Risk Estimates Uncertainty in Risk Management and the Precautionary Principle Human Health Exposure Assessment What are Receptors? How are Receptors Exposed to Environmental Stressors? Human Exposure Assessment Assessing Exposure Factors and Data Issues to Be Considered When Performing an Exposure Assessment The Concentration Term Fate and Transport Models Accounting For Uncertainty In Exposure Factors Toxicity Assessment for Human Health Risk Assessment Mode of Action and General Aspects of Toxicity Homeostasis and Thresholds Historical Perspective on Toxicity Testing Timescale and Nature of Adverse Effects Dose-Response Assessment Low Dose Extrapolation-Two Types of Toxicity Factors Computational Methods in Toxicity Assessment Mixtures Accounting For Uncertainty in Toxicity Factors Toxicity Factors for Regulation Risk Characterization Hazard Quotient for Threshold Effects Risk Estimation for Non-Threshold Effects Cumulative and Aggregate Risk The Possibility of Compounding Conservatism in Both Exposure and Toxicity The Precautionary Principle Utility of Risk Characterization for Decision Making Ecological Risk Assessment Statutory Aspects of ERA at EPA and the Role of Natural Resource Trustees ERA Under REACH Ecological Risk Assessment as Practiced By EPA Methodology for ERA under REACH Science Policy of ERA The Future of Risk Assessment In Vitro Testing and ¿Omics-Toxicity Testing in the 21st Century Science and Decisions: Advancing Risk Assessment Recommendations for Improving IRIS in the 2011 NAS Review of the Formaldehyde Risk Assessment Possible Future Scenarios for Risk Assessment: Scientific, Social and Political Factors in Societal Decision Making Appendix A: Useful Methods and Algorithms for Probabilistic Risk Assessment (PRA).