This issue of Physical Medicine and Rehabilitation Clinics of North America is devoted to "e;Difficult to Treat Pain Syndromes,"e; and is edited by Adam L. Schreiber, DO of the Jefferson Medical College of Thomas Jefferson University. Articles in this issue will include: Carpal Tunnel Syndrome Diagnosis; Non-surgical Treatment of Carpal Tunnel Syndrome; Parsonage Turner Syndrome Diagnosis and Treatment; Trochanteric Pain Syndrome Diagnosis and Treatment; Complex Regional Pain Syndrome Diagnosis and Treatment; Discogenic Spine Pain Syndrome Diagnosis and Treatment; Failed Back Surgery Syndrome Diagnosis and Treatment; Myofascial Pain Syndrome Diagnosis and Treatments; Opioid Syndrome Diagnosis and Treatment; Spinal Cord Pain Syndrome Diagnosis and Treatment; Cerebral Vascular Accident Hemishoulder Pain Syndrome Diagnosis and Treatment; and Cancer Pain Syndromes.