When the Rosens moved to New Rochelle, New York in 1973, Jonathan Rosen and Michael Laudor became inseparable. Both children of professors, the boys were best friends and fierce rivals who soon followed each other to Yale University. Michael blazed through Yale in three years, graduating summa cum laude and landing a top-flight consulting job. Then one day, Jonathan received a devastating call: Michael had suffered a psychotic break and was in the locked ward of a psychiatric hospital. Diagnosed with schizophrenia, Michael was still in hospital when he learned he'd been accepted to Yale Law School, and living in a halfway house when he decided, against all odds, to enroll. Still battling delusions, he managed to graduate, and after his triumphant story was featured in The New York Times , sold a memoir for a vast sum. Ron Howard bought film rights, completing the dream for Michael and his tirelessly supportive girlfriend Carrie, and Brad Pitt was set to star. But then Michael, in the grip of psychosis, committed a horrific act that made him a front-page story of an entirely different sort.

The Best Minds is Jonathan Rosen's powerful account of an American tragedy, set in the final decades of the American century, an era that coincided with the emptying out of state mental hospitals. It is a story about the bonds of friendship, the price of delusion and the mystery of identity. Tender, funny, and harrowing by turns, The Best Minds is both a beautifully rendered coming of age story and an indictment of the profound neglect of mental illness in our society.