SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study 1. National Trends 2. Regional Trends 3. State Trends 4. Sub-State Trends 5. Geospatial Analysis 6. Causality Criteria SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011. 7.
National Trends 8. Regional Trends 9. State Trends 10. Geospatial Analysis 11. Changes in State Trends 12. Legal Status and Autism 13. Geospatial Analysis of Legal Status and Autism SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity 14. Drug Use by Race 15.
Drugs and Defects Overview 16. Chromosomal Anomalies: Anomalies 1:5 17. Gastroschisis: Anomaly 6 18. Atrial Septal Defect (Secundum): Anomaly 7 19. Cardiovascular Defects of Interest: Anomalies 8-11 20. Hawaiian - American Review: Anomalies 12-37 21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses 22. General Introduction and Overview 23.
Sequential Analysis of Cancer Types 24. Geospatiotemporal Modelling - Fitted Values 25. Geospatiotemporal Modelling - Matrix Multiplication 26. Summary of Geospatiotemporal Modelling 27. Overall Conclusions SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail. 28. Epigenetics of Cannabinoids - Introduction 29. Epigenetics of Cannabinoids - Historical Studies 30.
Epigenetics of Cannabinoids - Longitudinal Sperm Study - Overview 31. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Stem Cells 32. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Chromosomes 33. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Brain 34. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Cardiovasculature 35. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Other Organs 36. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Carcinogenesis 37. Epigenetics of Cannabinoids - Accelerated Aging.