About the Editors xi List of Contributors xiii Foreword xviii Preface xix Section 1 Pathology as the Foundation of Medicine 1 1 Introduction to Pathology 3 S. R. Prabhu and Suja Pillai 2 Global Scenario, Aetiology and Risk Factors Associated with Oral and Maxillofacial Diseases: An Overview 11 Nesa Aurlene Jayadhas and Santosh Kumar Tadakamadla 3 The Role of Laboratory Diagnosis in Oral and Maxillofacial Pathology: An Overview 27 Hannah Walsh and Daniel J. Brierley Section 2 Homeostasis and Cellular Pathology 39 4 Homeostasis and Influences of Environment and Nutrition 41 A. V. Chalapathi Rao and S. R. Prabhu 5 Cellular Structure and Function 51 Suheyla Kaya Copyrighted Material 6 Cell Injury: Causes, Mechanisms and Responses 64 S.
R. Prabhu 7 The Structure and Function of the Oral Mucosa 82 Gargi Sarode and Sachin Sarode 8 Cellular Mechanisms of Ageing of Oral Tissues 99 Jeremy Lau, Agnieszka Frydrych and Omar Kujan 9 Endocrine and Metabolic Dysfunction and Oro- Facial Diseases 108 Prazwala Chirravur and Pradeep Chirravur Section 3 Defence Mechanisms Against Disease 133 10 Immunity and Host Defence Mechanisms in Oral Health and Disease 135 Irene Lafuente-Ibáñez de Mendoza and José M. Aguirre-Urizar 11 Immune Dysfunctions Affecting the Oro-Facial Complex 147 Yeshwant Rawal 12 Pathology of Inflammation and Inflammatory Diseases of the Oro- Facial Complex: An Overview 175 S. R. Prabhu 13 Cellular and Molecular Mechanisms of Healing of Cutaneous and Oral Mucosal Wounds 196 H. Ibrahim Korkmaz and Susan Gibbs 14 Healing of the Dental Pulp and Periodontal Tissues, Extraction Socket and BoneFracture 204 Sachin Sarode and Gargi Sarode Section 4 Clinical Genetics and Developmental Pathology 227 15 The Human Genome and Inheritance: Key Concepts 229 Yucel Erbilgin and Muge Sayitoglu 16 Heritable Diseases with Examples Involving the Oro- Facial Complex 245 Fadi Titinchi and Johan Opperman 17 Non- heritable Developmental Disorders with Examples Involving the Oral- Maxillofacial Complex 274 John Anthony Ozolek Section 5 Infectious and Systemic Diseases 293 18 Human Microbiome in Health and Disease with Reference to Dysbiosis in Dental Caries and Periodontal Diseases 295 Preethi Balan, Nadeeka Udawatte and Chaminda Jayampath Seneviratne 19 Pathology of Infection and Infectious Diseases of the Oro-Facial Complex 310 Nagamani Narayana and John Casey 20 Oral-systemic Link and Its Impact on General and Oral Health 339 Dáire Shanahan and Sarah Jane George 21 Orofacial Manifestations of Systemic Diseases: An Overview 362 Philip Atkin 22 Adverse Drug Reactions in the Orofacial Complex 377 Sue-Ching Yeoh Section 6 Disorders of Cell and Tissue Growth 407 23 Neoplasia: Basic Concepts 409 Omar Kujan and Philip Sloan 24 Molecular Basis of Cancer 415 Lalima Tiwari and Omar Kujan 25 Host Defences Against Cancer 429 Andreia Bufalino 26 WHO Classification of Tumours: An Overview 440 Muhammed Yakin and Richard Logan 27 Dysplasia, Precancer and Oral Potentially Malignant Disorders 449 Agnieszka Frydrych and Omar Kujan Section 7 Neoplastic Diseases of the Oral Mucosa and Salivary Glands 475 28 Global Burden, Risk factors and Pathobiology of Malignant Neoplasms of the Oral Mucosa and the Oropharynx 477 Paul Hankinson and Syed Ali Khurram 29 Presentation, Diagnosis and Prognosis of Squamous Cell Carcinomas of the Oral Mucosa and Oropharynx 498 Selvam Thavaraj and Adam Jones 30 Global Burden, Classification, Pathobiology, Genetics and Prognosis of Salivary Gland Neoplasms 531 Lucas Lacerda de Souza, Marcio Ajudarte Lopes, Pablo Agustin Vargas and Syed Ali Khurram Section 8 Diseases of the Oral and Maxillofacial Skeleton 567 31 Classification and Pathogenesis of Odontogenic and Non- odontogenic Jaw Cysts 569 Paul M. Speight and Merva Soluk Tekkesin 32 Global Burden, Pathobiology, Genetics and Behaviour of Odontogenic Neoplasms 585 Keith Hunter and Merva Soluk Tekkesin 33 Pathogenesis and Behaviour of Fibro- osseous and Giant- Cell Lesions of the Jaw Bones 604 Lisette Collins and Merva Soluk Tekkesin Section 9 Pain Disorders 615 34 Pathophysiology of Orofacial Pain 617 Janani Ravichandran, Guru O., Ramesh Balasubramaniam and Barry Sessle 35 Genetics, Lifestyle and Psychosocial Considerations in Orofacial Pain 639 Lasanthini Weerakkody, Jeremy Lau, Kavitha Vegunta, Davis C.
Thomas and Ramesh Balasubramaniam Index 658.