In this volume, Martha Nochimson engages in a study of screen couple chemistry. She begins by classifying various types of couples to define what sets the synergistic couple apart from other onscreen pairings. Then she moves into extended discussions of four enduring screen couples: Maureen O'Sullivan/Johnny Weissmuller, Myrna Loy/William Powell, Fred Astaire/Ginger Rogers, and Katharine Hepburn/Spencer Tracy. Using theories of neuroscience, she demonstrates that their onscreen chemistry is a very real phenomenon, powerful enough to subvert conventional formulations of male/female relations. Material she has uncovered in the infamous Production Code Administration files illuminates the historical context of her contentions. Finally, Nochimson traces the screen couple to its present-day incarnation in such pairs as Woody Allen/Diane Keaton, Scully/Mulder of The X-Files, and Cliff/Claire Huxtable of The Cosby Show.