Emi is a deathly-thin runaway living in the streets of Tokyo. Marcus is a high school student in California with a knack for attracting trouble. Blanca is a permanently ill Peruvian girl, sealed away in her hospital room. When these adolescents receive the visit of a fourth teenager, the mysterious Dan Moors, their lives are thrown into chaos. As the truth behind their turbulent pasts unravels and they begin to develop unusual skills, Dan must find a way to unite them against a supernatural six-year-old and a dangerous cult bent on using the teens' abilities to end the world.