Preface to the fourth edition 6 Preface to the first edition 6 Glossary 7 Normal values 8 About the companion website 9 Part 1 Basic physiology and practice 1 Haemopoiesis: physiology and pathology 10 2 Normal blood cells I: red cells 14 3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18 4 Normal blood cells III: lymphocytes 20 5 Lymph nodes, the lymphatic system and the spleen 23 6 Clinical assessment 24 7 Laboratory assessment 26 Part 2 Red cell disorders 8 General aspects of anaemia 30 9 Iron I: physiology and deficiency 33 10 Iron II: overload and sideroblastic anaemia 36 11 Megaloblastic anaemia I: vitamin B12 (B12) and folate deficiency ? biochemical basis, causes 38 12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40 13 Haemolytic anaemias I: general 42 14 Haemolytic anaemias II: inherited membrane and enzyme defects 44 15 Haemolytic anaemias III: acquired 46 16 Haemolytic anaemias IV: genetic defects of haemoglobin ? thalassaemia 48 17 Haemolytic anaemias V: genetic defects of haemoglobin ? sickle cell disease 52 Part 3 Benign disorders of white cells 18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54 19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56 Part 4 Haematological malignancies 20 Introduction to Haematological malignancy: basic mechanisms 58 21 General aspects of treatment 61 22 Acute leukaemia I: classifi cation and diagnosis 64 23 Acute leukaemia II: treatment and prognosis 68 24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70 25 Myelodysplasia (myelodysplastic syndromes) 72 26 Myeloproliferative disorders I: introduction 74 27 Myeloproliferative disorders II: polycythaemia rubra vera 76 28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofi brosis and systemic mastocytosis 78 29 Chronic lymphocytic leukaemia 80 30 Multiple myeloma and plasma cell disorders 83 31 Lymphoma I: introduction 86 32 Lymphoma II: Hodgkin lymphoma 88 33 Lymphoma III: non-Hodgkin lymphoma ? aetiology and classification 90 34 Lymphoma IV: clinical and laboratory features of more common subtypes 92 35 Lymphoma V: treatment and prognosis 94 Part 5 Treatment and procedures 36 Bone marrow failure 96 37 Haematological effects of drugs 98 38 Stem cell transplantation 100 Part 6 Haemostasis 39 Normal haemostasis I: vessel wall and platelets 102 40 Normal haemostasis II: coagulation factors and fi brinolysis 104 41 Disorders of haemostasis I: vessel wall and platelets 106 42 Disorders of haemostasis II: inherited disorders of coagulation 108 43 Disorders of haemostasis III: acquired disorders of coagulation 110 44 Thrombosis and anti-thrombotic therapy 112 45 Anticoagulation 115 Part 7 Haematological aspects of tropical disease 46 Haematological aspects of tropical diseases 118 47 Haematology of pregnancy and infancy 120 Part 8 Blood transfusion 48 Blood transfusion I 122 49 Blood transfusion II 124 Appendix: cluster of differentiation nomenclature system 127 Index 129.