1. Pathophysiological, toxicological and immunoregulatory roles of reactive oxygen and nitrogen species (RONS) 2. Biological mechanisms of reactive oxygen species (ROS) 3. Cellular signaling pathways with reactive oxygen species (ROS) 4. Manganese as the essential element in oxidative stress, and metabolic diseases 5. Affected energy metabolism is primal cause of manganese toxicity 6. Heavy metals and free radicals-induced cell death mechanisms 7. Cytotoxic mechanisms of xenobiotic heavy metals on oxidative stress 8.

Oxidative stress and oxidative damage-induced cell death 9. Cell death mechanisms-apoptosis pathways and their implications in toxicology 10. Programmed cell death mechanisms and nanoparticles toxicity 11. Endoplasmic reticulum stress (ERS) and associated ROS in disease pathophysiology applications 12. Endoplasmic reticulum (ER) stress-induced cell death mechanism 13.Modulation of endoplasmic reticulum (ER) stress of nanotoxicology for nanoparticles (NPs) 14. Nanoparticle cellular uptake and intracellular targeting on reactive oxygen species (ROS) in biological activities 15. Metal nanoparticles (MNPs) and particulate matter (PM) induce toxicity 16.

Mechanisms for nanoparticles-mediated oxidative stress 17. Nanotechnological modifications of nanoparticles on reactive oxygen and nitrogen species (RONS) 18. Medical imaging the complexity of nanoparticles and ROS dynamics in vivo for clinical diagnosis application 19.Titanium dioxide nanoparticles induced cytotoxicity, genotoxicity-generation of reactive oxygen species and cell damage 20. Toxicity of ZnO nanoparticles induced reactive oxygen species and cancer cells 21. Silver nanoparticles induce cellular cytotoxicity, genotoxicity, DNA damage and cell death 22.Correlations between oxidative stress and aligning nanoparticles safety assessments 23. Effects of interactions between antioxidant defenses therapy and ROS 24.

FDA breakthrough (BT)- - drug therapy designations for clinical evidence Appendix: List of abbreviations.