At the ripe old age of thirty-two, former wild child Isabel "Izzy" Spellman has finally agreed to take over the family detective business. The transition won't be smooth. First among her priorities as head of Spellman Investigations is to dig up some dirt on the competition, slippery ex-cop Rick Harkey. Next, faced with a puzzling missing-person's case she recruits an actor friend, Len, to infiltrate the home of an ageing millionaire as an undercover butler. Meanwhile, Izzy is being blackmailed by her mother to commit to regular blind dates with promising professionals - an arrangement that doesn't thrill Connor, Izzy's soon to become Ex-boyfriend No. 12. At Spellman headquarters, it's business as unusual. Doorknobs and light fixtures are disappearing every day, Mom's been spotted crying in the pantry and just when it looks like things can't go more haywire, little sister Rae's internship researching pro bono legal cases leads the youngest Spellman to launch a campaign that could spring an innocent man from jail - or land Rae in it.

It just goes to show, however many Spellman Family Rules are put in place in an attempt to hold the family together, Izzy will never be able to follow Rule No. 1: Act Normal.