Composition and Function of the Interstitial Fluid Definition of Interstitial Fluid Extravasation Cell Secretion in Interstitial Space Connectivity of the Interstitial Fluid and Other Extravascular Fluids Relationship of Interstitial Fluid to Lymph Structure of the Interstitium Heterogeneity in the Interstitium Methods for Obtaining Interstitial Fluid and Some Diagnostic Applications Transport of Drugs and Biologicals in Interstitial Fluid Transport of Drugs in the Interstitial Space. Transport of Biologicals in the Interstitial Space. Tumor Interstitial Fluid Chapter 2 - The Extracellular Matrix, Basement Membrane and Glycocalyx Matrices which Modulate Interstitial Fluid Composition The Extracellular Matrix Basement Membrane Glycocalyx Chapter 3 - The Biochemistry of Hyaluronan in the Interstitial Space Hyaluronan Introduction to Hyaluronan Physical Characteristics of Hyaluronan The Effect of Protein on Hyaluronan Conformation Solvent and Hyaluronan Hyaluronan in the Interstitial Space Effect of Hyaluronan on Enzyme Activity Specific Interaction of Hyaluronan with Receptors (Hyaldherins) CD44 RHAMM Other Cell Surface Receptors for Hyaluronan Hyaluronan Binding to Other Hyaldherins Low Molecular Weight Hyaluronan Hyaluronan as a Therapeutic Hyaluronidase and Drug Delivery in the Interstitial Space Proteolysis in the Interstitium Proteolytic Enzymes in the Interstitial Space ADAM Proteases ADAMTS Proteases Comment on Proteolytic Enzymes in the Interstitial Space The Fibrinolytic System in the Interstitial Space Components of the fibrinolytic system The Fibrinolytic System in the Interstitial Space Origin of Components of the Fibrinolytic System Found in the Interstitium Effect of Hyaluronan on Components of Fibrinolytic System. Urokinase-Type Plasminogen Activator Urokinase-Type Plasminogen Activator Receptor (CD87) Activation of Plasminogen on Bacterial Surfaces Plasminogen Receptors on Eukaryotic Cells Plasminogen and Plasmin Vitronectin Plasminogen Activator Inhibitor 1 (PAI-1; SerpinE1) Plasminogen Activator Inhibitor- 2 (PAI-2; SerpinB2) Plasminogen Activator Inhibitor 3 (PAI-3) α2-Plasmin inhibitor (SerpinF2) Kallikrein in the Interstitial Space Kallikrein Plasma Kallikrein Tissue Kallikrein (KLK1) and Kallikrein-Related Peptidases Miscellaneous Observations on Kallikreins and Other Kinin-forming Enzymes in the Interstitial Space Hyaluronan and KLK1 Kinins Matrix Metalloproteinases in the Interstitial Space Matrix Metalloproteinases Activation of Matrix Metalloproteinases Membrane-Bound Matrix Metalloproteinases Matrix Metalloproteinases and Regulatory Proteolysis Matrix Metalloproteinases as Biopharmaceuticals Development of Inhibitors of Matrix Metalloproteinases for Therapeutic Use Substrate Specificity of Matrix Metalloproteinases. Tissue Inhibitors of Metalloproteinases (TIMPs) Chelation of Zinc Ions and Inhibition of Matrix Metalloproteinases. Compartmentalization and Regulation of Matrix Metalloproteinases. Coagulation Factors in the Interstitial Space Coagulation factors and their regulation in the interstitial space Coagulation Factors in Lymph and Interstitial Fluid Prothrombin Fibrinogen Fibrinogen and Hyaluronan Factor VII, Factor VIIa, and Tissue Factor Regulation of Tissue Factor in the Interstitial Space and Cryptic Tissue Factor Activity of Tissue Factor, Factor VII/VIIa, and Tissue Factor/Factor VIIa not Related to Blood Coagulation Factor VII and VIIa in the Interstitial Space Tissue Factor/Factor VIIa and Interstitial Pathology Tissue Factor/Factor VIIa and Tumor Development Intrinsic Coagulation Pathway in the Interstitium Factor IX Factor VIII and von Willebrand Factor Thrombin Formation of Thrombin in the Interstitial Space Factors Influencing the Activity of Thrombin in the Interstitial Space Effect of Hyaluronan on Thrombin Activity Substrates for Thrombin in the Interstitial Space The Role of Thrombin in Interstitial Fibrosis Protease Inhibitors in the Interstitial Space Proteolytic Regulation in the Interstitial Space Antithrombin Latent Antithrombin Plasminogen Activator Inhibitor-1 α1-Antitrypsin Heparin Cofactor II α2-Macroglobulin Tissue Inhibitors of Metalloproteinases (TIMPs) titial Fluid Composition The Extracellular Matrix Basement Membrane Glycocalyx Chapter 3 - The Biochemistry of Hyaluronan in the Interstitial Space Hyaluronan Introduction to Hyaluronan Physical Characteristics of Hyaluronan The Effect of Protein on Hyaluronan Conformation Solvent and Hyaluronan Hyaluronan in the Interstitial Space Effect of Hyaluronan on Enzyme Activity Specific Interaction of Hyaluronan with Receptors (Hyaldherins) CD44 RHAMM Other Cell Surface Receptors for Hyaluronan Hyaluronan Binding to Other Hyaldherins Low Molecular Weight Hyaluronan Hyaluronan as a Therapeutic Hyaluronidase and Drug Delivery in the Interstitial Space Proteolysis in the Interstitium Proteolytic Enzymes in the Interstitial Space ADAM Proteases ADAMTS Proteases Comment on Proteolytic Enzymes in the Interstitial Space The Fibrinolytic System in the Interstitial Space Components of the fibrinolytic system The Fibrinolytic System in the Interstitial Space Origin of Components of the Fibrinolytic System Found in the Interstitium Effect of Hyaluronan on Components of Fibrinolytic System. Urokinase-Type Plasminogen Activator Urokinase-Type Plasminogen Activator Receptor (CD87) Activation of Plasminogen on Bacterial Surfaces Plasminogen Receptors on Eukaryotic Cells Plasminogen and Plasmin Vitronectin Plasminogen Activator Inhibitor 1 (PAI-1; SerpinE1) Plasminogen Activator Inhibitor- 2 (PAI-2; SerpinB2) Plasminogen Activator Inhibitor 3 (PAI-3) α2-Plasmin inhibitor (SerpinF2) Kallikrein in the Interstitial Space Kallikrein Plasma Kallikrein Tissue Kallikrein (KLK1) and Kallikrein-Related Peptidases Miscellaneous Observations on Kallikreins and Other Kinin-forming Enzymes in the Interstitial Space Hyaluronan and KLK1 Kinins Matrix Metalloproteinases in the Interstitial Space Matrix Metalloproteinases Activation of Matrix Metalloproteinases Membrane-Bound Matrix Metalloproteinases Matrix Metalloproteinases and Regulatory Proteolysis Matrix Metalloproteinases as Biopharmaceuticals Development of Inhibitors of Matrix Metalloproteinases for Therapeutic Use Substrate Specificity of Matrix Metalloproteinases.
Tissue Inhibitors of Metalloproteinases (TIMPs) Chelation of Zinc Ions and Inhibition of Matrix Metalloproteinases. Compartmentalization and Regulation of Matrix Metalloproteinases. Coagulation Factors in the Interstitial Space Coagulation factors and their regulation in the interstitial space Coagulation Factors in Lymph and Interstitial Fluid Prothrombin Fibrinogen Fibrinogen and Hyaluronan Factor VII, Factor VIIa, and Tissue Factor Regulation of Tissue Factor in the Interstitial Space and Cryptic Tissue Factor Activity of Tissue Factor, Factor VII/VIIa, and Tissue Factor/Factor VIIa not Related to Blood Coagulation Factor VII and VIIa in the Interstitial Space Tissue Factor/Factor VIIa and Interstitial Pathology Tissue Factor/Factor VIIa and Tumor Development Intrinsic Coagulation Pathway in the Interstitium Factor IX Factor VIII and von Willebrand Factor Thrombin Formation of Thrombin in the Interstitial Space Factors Influencing the Activity of Thrombin in the Interstitial Space Effect of Hyaluronan on Thrombin Activity Substrates for Thrombin in the Interstitial Space The Role of Thrombin in Interstitial Fibrosis Protease Inhibitors in the Interstitial Space Proteolytic Regulation in the Interstitial Space Antithrombin Latent Antithrombin Plasminogen Activator Inhibitor-1 α1-Antitrypsin Heparin Cofactor II α2-Macroglobulin Tissue Inhibitors of Metalloproteinases (TIMPs) e and Drug Delivery in the Interstitial Space Proteolysis in the Interstitium Proteolytic Enzymes in the Interstitial Space ADAM Proteases ADAMTS Proteases Comment on Proteolytic Enzymes in the Interstitial Space The Fibrinolytic System in the Interstitial Space Components of the fibrinolytic system The Fibrinolytic System in the Interstitial Space Origin of Components of the Fibrinolytic System Found in the Interstitium Effect of Hyaluronan on Components of Fibrinolytic System. Urokinase-Type Plasminogen Activator Urokinase-Type Plasminogen Activator Receptor (CD87) Activation of Plasminogen on Bacterial Surfaces Plasminogen Receptors on Eukaryotic Cells Plasminogen and Plasmin Vitronectin Plasminogen Activator Inhibitor 1 (PAI-1; SerpinE1) Plasminogen Activator Inhibitor- 2 (PAI-2;.