GM3 Signaling

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Author(s):	Kim, Cheorl-Ho
ISBN No.:	9789811556548
Pages:	vii, 138
Year:	202107
Format:	Trade Paper
Price:	$ 234.59
Dispatch delay:	Dispatched between 7 to 15 days
Status:	Available

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Synopsis
Table of contents
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1. History of sialic acids, gangliosides and GM3.- 2. Synthesis of GM3.- 3. Molecular localization of GM3 in cells.- 4. Basic function of GM3 as an interacting molecule.

- 5. GD3 mimetics with a neurite forming capacity.- 6. GM3 as a pathogenic infection receptor.- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis.- 8. GM3 has an anti-tumor capacity.

- 9. GM3 suppresses tumor angiogenesis.- 10. Interaction between EGFR and GM3.- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling.- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase.

- 13. VEGFR-GM3 interaction in angiogenesis.- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis.- 15. GM3 interacts with TGFÎ² Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation.- 16. Galectin-1 promotes tumor growth and escapes immune surveillance.

- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing.- 18. GM3, caveolin-1 and insulin receptor in insulin resistance.- 19. GM3 suppresses arthritis.- 20. GM3 protects cochlear hair cells and hearing from corti degeneration.

- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1.- 22. GM3 in leukemic cells into terminal differentiation.- 23. Î±2,3-Sialyllactose (3SL) or Î±2,6-sialyllactose (6SL) of GM3 glycan in innate immunity.

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