ISCA 2006 covers innovative ideas and presents quantified experience in the area of computer architecture. This thirty-third proceedings focuses on architecture as a whole while also looking at architectures for specific applications and system architecture issues. The papers focus on all aspects of computer architecture, including processor architectures, memory hierarchy subsystems, multiprocessors and multicomputers, storage and interconnect subsystems, application-specific, and reconfigurable and embedded architectures. Other topics include power-efficient architectures, dependable architectures, impact of technology on architecture, impact of application characteristics on architecture, and architectures for emerging technologies and applications.