Preface. PART I: PRINCIPLES OF BIOREACTOR MODELLING. 1. MODELLING PRINCIPLES. Fundamentals of Modelling. Development and Meaning of Dynamic Differential Balances. Formulation of Balance Equations. 2.

BASIC BIOREACTOR CONCEPTS. Information for Bioreactor Modelling. Bioreactor Operation. 3. BIOLOGICAL KINETICS. Enzyme Kinetics. Simple Microbial Kinetics. Structured Kinetic Models.

4. BIOREACTOR MODELLING. General Balances for Tank-type Biological Reactors. Modelling Tubular Plug Flow Bioreactors. 5. MASS TRANSFER. Mass Transfer in Biological Reactors. Interphase Gas-Liquid Mass Transfer.

General Oxygen Balances for Gas-Liquid Transfer. Models for Oxygen Transfer in Large Scale Bioreactors 6. DIFFUSION AND BIOLOGICAL REACTION IN IMMOBILIZED BIOCATALYST SYSTEMS. External Mass Transfer. Internal Diffusion and Reaction within Biocatalysts. 7. AUTOMATIC BIOPROCESS CONTROL FUNDAMENTALS. Elements of Feedback Control.

Types of Controller Action. Controller Tuning. Advanced Control Strategies Concepts for Bioprocess Control. REFERENCES. PART II: DYNAMIC BIOPROCESS SIMULATION EXAMPLES AND THE BERKELEY MADONNA SIMULATION LANGUAGE. 8. SIMULATION EXAMPLES OF BIOLOGICAL REACTION PROCESSES USING BERKELEY MADONNA. Introductory Examples.

Batch Reactors. Fed Batch Reactors. Continuous Reactors. Oxygen Uptake Systems. Controlled Reactors. Diffusion Systems. Multi-Organism Systems. Membrane and Cell Retention Reactors.

9. APPENDIX: USING THE BERKELEY MADONNA LANGUAGE. 10. ALPHABETICAL LIST OF EXAMPLES. 11. INDEX.